Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[tRNAIle2]-cytidine34 + L-lysine + ATP | Bacillus subtilis | - |
[tRNAIle2]-lysidine34 + AMP + diphosphate + H2O | - |
? | |
[tRNAIle2]-cytidine34 + L-lysine + ATP | Bacillus subtilis 168 | - |
[tRNAIle2]-lysidine34 + AMP + diphosphate + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus subtilis | - |
- |
- |
Bacillus subtilis 168 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[tRNAIle2]-cytidine34 + L-lysine + ATP | - |
Bacillus subtilis | [tRNAIle2]-lysidine34 + AMP + diphosphate + H2O | - |
? | |
[tRNAIle2]-cytidine34 + L-lysine + ATP | - |
Bacillus subtilis 168 | [tRNAIle2]-lysidine34 + AMP + diphosphate + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TilS | - |
Bacillus subtilis |
tRNAIle-lysidine synthetase | - |
Bacillus subtilis |
General Information | Comment | Organism |
---|---|---|
malfunction | the absence of enzyme activity leads to a lack of modification of cytidine34 to lysidine in tRNA2IleLAU, (i.e. synthesis of tRNA2IleCAU), thereby rendering it inactive for translation of AUA codons. Strains of Bacillus subtilis carrying a deletion in the TilS gene can survive only in the presence of a mutant tRNA1Ile, whose anticodon wobble position is changed from G34 to U34 (tRNA1IleUAU) | Bacillus subtilis |