Activating Compound | Comment | Organism | Structure |
---|---|---|---|
N-acetyl-L-glutamate | i.e. NAG, dependent on the essential cofactor | Mus musculus | |
SIRT5 | a sirtuin enzyme, that deacetylates CPSI, which activates CPSI. During fasting, NAD in liver mitochondria increases, thereby triggering SIRT5 deacetylation of CPS1 and adaptation to the increase in amino acid catabolism. SIRT5 KO mice fail to up-regulate CPS1 activity and show elevated blood ammonia during fasting, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | deacetylation by SIRT5 activates CPSI | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
carbamoyl phosphate synthetase 1 | - |
Mus musculus |
CPS1 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | nutrient depletion does not increase CPS1 protein levels in wild-type or KO cells | additional information |
General Information | Comment | Organism |
---|---|---|
metabolism | CPS1 catalyzes the initial step of the urea cycle for ammonia detoxification and disposal | Mus musculus |