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Literature summary for 6.3.4.16 extracted from

  • Nakagawa, T.; Lomb, D.J.; Haigis, M.C.; Guarente, L.
    SIRT5 deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle (2009), Cell, 137, 560-570.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
N-acetyl-L-glutamate i.e. NAG, dependent on the essential cofactor Mus musculus
SIRT5 a sirtuin enzyme, that deacetylates CPSI, which activates CPSI. During fasting, NAD in liver mitochondria increases, thereby triggering SIRT5 deacetylation of CPS1 and adaptation to the increase in amino acid catabolism. SIRT5 KO mice fail to up-regulate CPS1 activity and show elevated blood ammonia during fasting, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information deacetylation by SIRT5 activates CPSI Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
carbamoyl phosphate synthetase 1
-
Mus musculus
CPS1
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus nutrient depletion does not increase CPS1 protein levels in wild-type or KO cells additional information

General Information

General Information Comment Organism
metabolism CPS1 catalyzes the initial step of the urea cycle for ammonia detoxification and disposal Mus musculus