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Literature summary for 6.3.4.16 extracted from

  • Poyck, P.P.; Hoekstra, R.; Vermeulen, J.L.; van Wijk, A.C.; Chamuleau, R.A.; Hakvoort, T.B.; van Gulik, T.M.; Lamers, W.H.
    Expression of glutamine synthetase and carbamoylphosphate synthetase I in a bioartificial liver: markers for the development of zonation in vitro (2008), Cells Tissues Organs, 188, 259-269.
    View publication on PubMed
Search for more literature for 6.3.4.16

Application

Application Comment Organism
biotechnology ammonia elimination as functional marker in hepatocyte cultivation and zonation in a bioreactor, and construction of a bioartificial liver, overview Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Sus scrofa 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + NH3 + CO2 + H2O Sus scrofa CPS is the rate-determining enzyme of the urea cycle and catalyzes the conversion of ammonia and bicarbonate to carbamoylphosphate in the periportal and intermediate zones of a liver lobule, overview. The enzyme is responsible for ammonia elimination ADP + phosphate + carbamoyl phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Sus scrofa
-
liver dynamic expression pattern of the enzyme in hepatocytes of different zones of the liver lobule, overview Sus scrofa
-
additional information mechanism underlying metabolic zonation, overview Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + NH3 + CO2 + H2O
-
 Sus scrofa ADP + phosphate + carbamoyl phosphate
-
 ?
ATP + NH3 + CO2 + H2O CPS is the rate-determining enzyme of the urea cycle and catalyzes the conversion of ammonia and bicarbonate to carbamoylphosphate in the periportal and intermediate zones of a liver lobule, overview. The enzyme is responsible for ammonia elimination Sus scrofa ADP + phosphate + carbamoyl phosphate
-
 ?

Synonyms

Synonyms Comment Organism
CPS
-
 Sus scrofa
mitochondrial carbamoylphosphate synthetase I
-
 Sus scrofa

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Sus scrofa