Literature summary for 6.3.4.15 extracted from

Tieu, W.; Jarrad, A.M.; Paparella, A.S.; Keeling, K.A.; Soares da Costa, T.P.; Wallace, J.C.; Booker, G.W.; Polyak, S.W.; Abell, A.D.
Heterocyclic acyl-phosphate bioisostere-based inhibitors of Staphylococcus aureus biotin protein ligase (2014), Bioorg. Med. Chem. Lett., 24, 4689-4693 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
5-chloro-3-[4-(4-[5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl]-1H-1,2,3-triazol-1-yl)butyl]-1,3-benzoxazol-2(3H)-one	not inhibitory to human enzyme at 0.08 mM	Staphylococcus aureus
5-methyl-3-[4-(4-[5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl]-1H-1,2,3-triazol-1-yl)butyl]-1,3-benzoxazol-2(3H)-one	not inhibitory to human enzyme at 0.08 mM	Staphylococcus aureus

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	-	-	-

Synonyms

Synonyms	Comment	Organism
BPL	-	Staphylococcus aureus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00009	-	pH not specified in the publication, temperature not specified in the publication	Staphylococcus aureus	5-methyl-3-[4-(4-[5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl]-1H-1,2,3-triazol-1-yl)butyl]-1,3-benzoxazol-2(3H)-one
0.0006	-	pH not specified in the publication, temperature not specified in the publication	Staphylococcus aureus	5-chloro-3-[4-(4-[5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl]-1H-1,2,3-triazol-1-yl)butyl]-1,3-benzoxazol-2(3H)-one

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Release 2023.1 (January 2023)