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Literature summary for 6.3.4.15 extracted from
- Holocarboxylase synthetase: correlation of protein localisation with biological function (2010), Arch. Biochem. Biophys., 496, 45-52.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
| mitochondria | - |
Homo sapiens | - |
- |
| mitochondrion | - |
Homo sapiens | 5739 | - |
| additional information | isozyme subcellular localization, immunofluorescence study, overview | Homo sapiens | - |
- |
| nucleus | the longer Met58 isoform | Homo sapiens | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + biotin + apo-[acetyl-CoA carboxylase] | Homo sapiens | - |
AMP + diphosphate + acetyl-CoA carboxylase | - |
? |  |
| additional information | Homo sapiens | although mammals have multiple biotin-dependent enzymes there is only a single gene encoding holocarboxylase synthetase, HCS, responsible for all cellular biotinylation. The enzyme catalyzes the reactions of EC 6.3.4.10, EC 6.3.4.11, and EC 6.3.4.15, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
three isozymes that differ at the N-terminus | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293T cell | - |
Homo sapiens | - |
| HeLa cell | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| T-lymphocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + biotin + apo-[acetyl-CoA carboxylase] | - |
Homo sapiens | AMP + diphosphate + acetyl-CoA carboxylase | - |
? | |
| additional information | although mammals have multiple biotin-dependent enzymes there is only a single gene encoding holocarboxylase synthetase, HCS, responsible for all cellular biotinylation. The enzyme catalyzes the reactions of EC 6.3.4.10, EC 6.3.4.11, and EC 6.3.4.15, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HCS | - |
Homo sapiens |
| Holocarboxylase synthetase | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | holocarboxylase synthetase governs the cellular fate of the essential micronutrient biotin, i.e. vitamin H or B7 | Homo sapiens |
| physiological function | HCS is responsible for attaching biotin onto the biotin-dependent enzymes that reside in the cytoplasm and mitochondria | Homo sapiens |
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