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Literature summary for 6.3.4.14 extracted from

  • Smith, A.C.; Cronan, J.E.
    Dimerization of the bacterial biotin carboxylase subunit is required for acetyl coenzyme A carboxylase activity in vivo (2012), J. Bacteriol., 194, 72-78.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
E23R the mutant protein has a kcat value about 30% that of the wild type enzyme Escherichia coli
F363A the mutant has approximately 84% of the wild type activity Escherichia coli
R19E the mutant has about half the activity of the wild type protein Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + biotin-carboxyl-carrier protein + HCO3- Escherichia coli
-
ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
substr. MG1655
-

Purification (Commentary)

Purification (Comment) Organism
partial purification Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + biotin-carboxyl-carrier protein + HCO3-
-
Escherichia coli ADP + phosphate + carboxybiotin-carboxyl-carrier protein
-
?

Subunits

Subunits Comment Organism
dimer
-
Escherichia coli

Synonyms

Synonyms Comment Organism
AccC
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
ATP
-
Escherichia coli

General Information

General Information Comment Organism
physiological function dimerization of the biotin carboxylase subunit is required for acetyl coenzyme A carboxylase activity in vivo Escherichia coli