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Literature summary for 6.3.4.13 extracted from
- Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development (2009), Development, 136, 2601-2611.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | zygotic gart and paic mutants have pigmentation defects in which xanthophore and iridophore pigmentation is almost completely absent, and melanin-derived pigmentation is significantly decreased, even though pigment cells are present in normal amounts and distributions. Zygotic gart and paics mutants are also microphthalmic, resulting from defects in cell cycle exit of proliferative retinoblasts within the developing eye, severe phenotypes, overview | Danio rerio |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Danio rerio | the enzyme is trifunctional exhibiting phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, and phosphoribosylaminoimidazole synthetase activities, overview | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Danio rerio | - |
gene gart | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | - |
Danio rerio | - |
| eye | - |
Danio rerio | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme is trifunctional exhibiting phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, and phosphoribosylaminoimidazole synthetase activities, overview | Danio rerio | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Phosphoribosylglycinamide synthetase | - |
Danio rerio |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | gart and paics mutants have pigmentation defects and microphthalmia | Danio rerio |
| metabolism | the trifunctional enzyme catalyzes steps 2, 3, and 5 of inosine monophosphate synthesis, followed by paics encoded phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase, a bifunctional enzyme that catalyzes steps 6 and 7 of this process. Crucial requirement for maternally derived gart and paics. De novo purine synthesis pathway, overview | Danio rerio |
| physiological function | gart and paics function are required for eye growth. IMP feeds into an ATP pathway required for retinoblast proliferation and a GTP pathway required for pigmentation | Danio rerio |
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Release 2023.1 (January 2023)
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