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Literature summary for 6.3.4.10 extracted from

  • Murthy, P.N.A.; Mistry, S.P.
    In vitro synthesis of propionyl-CoA holocarboxylase by a partially purified mitochondrial preparation from biotin-deficient chicken liver (1974), Can. J. Biochem., 52, 800-803.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ADP
-
Gallus gallus
AMP
-
Gallus gallus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0033
-
biotin
-
Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Gallus gallus 5829
-
mitochondrion
-
Gallus gallus 5739
-

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
Gallus gallus AMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
?
CTP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] 28% of the activity relative to ATP Gallus gallus CMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
?
GTP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
Gallus gallus GMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
?
ITP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
Gallus gallus IMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
?
UTP + biotin + apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] 95% of the activity relative to ATP Gallus gallus UMP + diphosphate + [propanoyl-CoA:carbon-dioxide ligase (ADP-forming)]
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Gallus gallus