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Literature summary for 6.3.3.2 extracted from

  • Schirch, V.
    Purification of folate-dependent enzymes from rabbit liver (1997), Methods Enzymol., 281, 146-161.
    View publication on PubMed
Search for more literature for 6.3.3.2

Inhibitors

Inhibitors Comment Organism Structure
5-Formyltetrahydrohomofolate
-
 Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0002
-
 5-formyl-tetrahydropteroyl-pentaglutamate
-
 Oryctolagus cuniculus
0.0003
-
 ATP
-
 Oryctolagus cuniculus
0.008
-
 5-formyltetrahydrofolate
-
 Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ can replace Mg2+ Oryctolagus cuniculus
Co2+ can replace Mg2+ Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
13
-
-
 Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5-formyltetrahydrofolate
-
 Oryctolagus cuniculus ADP + phosphate + 5,10-methylenetetrahydrofolate
-
 ?
ATP + 5-formyltetrahydrofolate ATP in form of MgATP2- Oryctolagus cuniculus ADP + phosphate + 5,10-methenyltetrahydrofolate
-
 ?
ATP + 5-formyltetrahydrohomofolate
-
 Oryctolagus cuniculus ?
-
 ?
ATP + 5-formyltetrahydropteroyl-pentaglutamate
-
 Oryctolagus cuniculus ?
-
 ?
CTP + 5-formyltetrahydrofolate as effective as ATP Oryctolagus cuniculus CDP + phosphate + 5,10-methylenetetrahydrofolate
-
 ?