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Literature summary for 6.3.3.1 extracted from

  • Schrimsher, J.L.; Schendel, F.J.; Stubbe, J.
    Isolation of a multifunctional protein with aminoimidazole ribonucleotide synthetase, glycinamide ribonucleotide synthetase, and glycinamide ribonucleotide transformylase activities: characterization of aminoimidazole ribonucleotide synthetase (1986), Biochemistry, 25, 4356-4365.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.009
-
2-(formamido)-N1-(5-phosphoribosyl)acetamidine
-
Gallus gallus
0.078
-
ATP
-
Gallus gallus

Metals/Ions

Metals/Ions Comment Organism Structure
K+ absolutely required Gallus gallus
K+ optimal concentration: 150 mM Gallus gallus
Mg2+ optimal concentration: 20 mM Gallus gallus
Mg2+ absolutely required Gallus gallus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
133000
-
sucrose density gradient ultracentrifugation, trifunctional enzyme: AIR synthase, glycinamide ribonucleotide synthetase, and glycinamide ribonucleotide transformylase Gallus gallus
330000
-
gel filtration, trifunctional enzyme: aminoimidazole ribonucleotide synthase, glycinamide ribonucleotide synthetase, and glycineamide ribonucleotide transformylase Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
trifunctional enzyme with AIR synthetase activity, phosphoribosylglycinamide synthetase activity, and phosphoribosylglycinamide transformylase activity
-

Purification (Commentary)

Purification (Comment) Organism
trifunctional enzyme with AIR synthetase activity, phosphoribosylglycinamide synthetase activity, and phosphoribosylglycinamide transformylase activity Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Gallus gallus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.43
-
-
Gallus gallus

Storage Stability

Storage Stability Organism
-20°C, stable for many weeks Gallus gallus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine ATP in form of MgATP2- Gallus gallus ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole
-
?
ATP + 2-(formamido)-N1-(5-phosphoribosyl)acetamidine ir Gallus gallus ADP + phosphate + 1-(5-phosphoribosyl)-5-aminoimidazole
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.7
-
-
Gallus gallus

pH Range

pH Minimum pH Maximum Comment Organism
7.4 8.1 about 90% of maximal activity at pH 7.4 and 8.1 Gallus gallus