Crystallization (Comment) | Organism |
---|---|
- |
Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.044 | - |
UDP-N-acetylmuramate | - |
Escherichia coli | |
0.046 | - |
beta-Ala | - |
Escherichia coli | |
0.048 | - |
L-Ala | - |
Escherichia coli | |
0.13 | - |
ATP | - |
Escherichia coli | |
0.14 | - |
ATP | beta-chloro-L-Ala | Escherichia coli | |
0.19 | - |
beta-cyano-L-Ala | - |
Escherichia coli | |
0.2 | - |
L-Ala | 2-amino-tert-butylpropionate | Escherichia coli | |
0.22 | - |
UDP-N-acetyl-alpha-D-muramate | - |
Escherichia coli | |
0.36 | - |
benzyl L-alaninate | - |
Escherichia coli | |
0.44 | - |
L-Vinylglycine | - |
Escherichia coli | |
0.5 | - |
methyl L-alaninate | - |
Escherichia coli | |
0.59 | - |
ethyl L-alaninate | - |
Escherichia coli | |
1.1 | - |
DL-propargylglycine | - |
Escherichia coli | |
1.2 | - |
L-Ser | - |
Escherichia coli | |
3.8 | - |
L-Cys | - |
Escherichia coli | |
4.3 | - |
2-amino-n-butyric acid | - |
Escherichia coli | |
7.9 | - |
2-aminopropionamide | - |
Escherichia coli | |
10 | - |
Gly | - |
Escherichia coli | |
16 | - |
2-amino-N-hydroxymethyl propionamide | - |
Escherichia coli | |
25 | - |
L-Thr | - |
Escherichia coli | |
40 | - |
L-Ile | - |
Escherichia coli | |
62 | - |
N-(2-aminopropionyl)piperidine | - |
Escherichia coli | |
70 | - |
L-Val | - |
Escherichia coli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | support activity | Escherichia coli | |
Mg2+ | support activity | Escherichia coli | |
Mn2+ | supports activity | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + UDP-N-acetylmuramate + L-Ala | Escherichia coli | adds the first amino acid to the sugar moiety of the peptidoglycan precursor, catalyzing one essential step in cell wall biosynthesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + UDP-N-acetyl-alpha-D-muramate + L-alanine | - |
Escherichia coli | ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine | - |
? | |
ATP + UDP-N-acetylmuramate + 2-amino-benzylpropionate | - |
Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-2-amino-benzylpropionate | - |
? | |
ATP + UDP-N-acetylmuramate + 2-amino-ethylpropionate | - |
Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-2-amino-ethylpropionate | - |
? | |
ATP + UDP-N-acetylmuramate + 2-amino-methylpropionate | - |
Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-2-amino-methylpropionate | - |
? | |
ATP + UDP-N-acetylmuramate + 2-amino-N-butyric acid | - |
Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-2-amino-N-butyric acid | - |
? | |
ATP + UDP-N-acetylmuramate + 2-amino-N-hydroxymethyl propionamide | - |
Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-2-amino-N-hydroxymethylpropionamide | - |
? | |
ATP + UDP-N-acetylmuramate + 2-amino-propionamide | - |
Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-2-aminopropionamide | - |
? | |
ATP + UDP-N-acetylmuramate + 2-amino-tert-butylpropionate | - |
Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-2-amino-tert-butylpropionate | - |
? | |
ATP + UDP-N-acetylmuramate + benzyl L-alaninate | - |
Escherichia coli | ADP + phosphate + benzyl UDP-N-acetylmuramoyl-L-alanine | - |
? | |
ATP + UDP-N-acetylmuramate + beta-Ala | - |
Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-beta-Ala | - |
? | |
ATP + UDP-N-acetylmuramate + beta-chloro-L-Ala | - |
Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-beta-chloro-L-Ala | - |
? | |
ATP + UDP-N-acetylmuramate + beta-cyano-L-Ala | - |
Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-beta-cyano-L-Ala | - |
? | |
ATP + UDP-N-acetylmuramate + DL-propargylglycine | - |
Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-DL-propargylglycine | - |
? | |
ATP + UDP-N-acetylmuramate + DL-Ser | - |
Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-DL-Ser | - |
? | |
ATP + UDP-N-acetylmuramate + ethyl L-alaninate | - |
Escherichia coli | ADP + phosphate + ethyl UDP-N-acetylmuramoyl-L-alaninate | - |
? | |
ATP + UDP-N-acetylmuramate + Gly | - |
Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-Gly | - |
? | |
ATP + UDP-N-acetylmuramate + L-Ala | - |
Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala | - |
? | |
ATP + UDP-N-acetylmuramate + L-Ala | adds the first amino acid to the sugar moiety of the peptidoglycan precursor, catalyzing one essential step in cell wall biosynthesis | Escherichia coli | ? | - |
? | |
ATP + UDP-N-acetylmuramate + L-Cys | - |
Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-L-Cys | - |
? | |
ATP + UDP-N-acetylmuramate + L-Ile | - |
Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-L-Ile | - |
? | |
ATP + UDP-N-acetylmuramate + L-serine | - |
Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-L-serine | - |
? | |
ATP + UDP-N-acetylmuramate + L-Thr | - |
Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-L-Thr | - |
? | |
ATP + UDP-N-acetylmuramate + L-Val | - |
Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-L-Val | - |
? | |
ATP + UDP-N-acetylmuramate + L-vinylglycine | - |
Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-L-vinylglycine | - |
? | |
ATP + UDP-N-acetylmuramate + methyl L-alaninate | - |
Escherichia coli | ADP + phosphate + methyl UDP-N-acetylmuramoyl-L-alaninate | - |
? | |
ATP + UDP-N-acetylmuramate + N-(2-aminopropionyl)piperidine | - |
Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-N-(2-aminopropionyl)piperidine | - |
? | |
additional information | the enzyme hydrolyzes ATP in absence of L-Ala. This L-Ala independent activity is dependent upon the concentration of both ATP and UDP-N-acetylmuramate | Escherichia coli | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Escherichia coli | |
2.5 | - |
beta-Alanine | - |
Escherichia coli | |
5.17 | - |
L-Ile | - |
Escherichia coli | |
6.17 | - |
N-(2-aminopropionyl)piperidine | - |
Escherichia coli | |
11.7 | - |
2-amino-N-hydroxymethylpropionamide | - |
Escherichia coli | |
13.5 | - |
2-amino-benzylpropionate | - |
Escherichia coli | |
15.2 | - |
2-amino-ethylpropionate | - |
Escherichia coli | |
15.3 | - |
L-Vinylglycine | - |
Escherichia coli | |
16.3 | - |
L-Ala | - |
Escherichia coli | |
18.3 | - |
2-amino-propionamide | - |
Escherichia coli | |
20 | - |
L-Cys | - |
Escherichia coli | |
20 | - |
DL-propargylglycine | - |
Escherichia coli | |
20 | - |
beta-chloro-Ala | - |
Escherichia coli | |
21.7 | - |
Gly | - |
Escherichia coli | |
21.7 | - |
L-Val | - |
Escherichia coli | |
21.7 | - |
2-amino-tert-butylpropionate | - |
Escherichia coli | |
23.3 | - |
L-Thr | - |
Escherichia coli | |
25 | - |
L-Ser | - |
Escherichia coli | |
25 | - |
2-amino-n-butyric acid | - |
Escherichia coli | |
26.7 | - |
beta-cyano-L-Ala | - |
Escherichia coli | |
28.3 | - |
2-amino-methylpropionate | - |
Escherichia coli |