Literature summary for 6.3.2.6 extracted from

O'Donnell, A.F.; Tiong, S.; Nash, D.; Clark, D.V.
The Drosophila melanogaster ade5 gene encodes a bifunctional enzyme for two steps in the de novo purine synthesis pathway (2000), Genetics, 154, 1239-1253.

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Cloned(Commentary)

Cloned (Comment)	Organism
functional complementation of Escherichia coli purC purine auxotroph	Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate	Drosophila melanogaster	-	ADP + phosphate + (S)-2-[5-amino1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate	-	?

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	Q9I7S8	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate	bifunctional enzyme having also 5-aminoimidazole ribonucleotide carboxylase, i.e. AIRc, activity	Drosophila melanogaster	ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate	-	?
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate	-	Drosophila melanogaster	ADP + phosphate + (S)-2-[5-amino1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate	-	?

Synonyms

Synonyms	Comment	Organism
ade5	-	Drosophila melanogaster
AIRc-SAICARs	-	Drosophila melanogaster

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Release 2023.1 (January 2023)