Literature summary for 6.3.2.51 extracted from

Manoj, N.; Strauss, E.; Begley, T.P.; Ealick, S.E.
Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution (2003), Structure, 11, 927-936.

Search for more literature for 6.3.2.51

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli B834(DE3) cells	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop vapor diffusion method, using 24% polyethyleneglycol monomethyl ether 2000, 120 mM (NH4)2SO4, and 100 mM Tris-HCl (pH 8.5)	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + (R)-4'-phosphopantothenate + L-cysteine	Homo sapiens	-	AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9HAB8	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-NTA resin column chromatography	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + (R)-4'-phosphopantothenate + L-cysteine	-	Homo sapiens	AMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine	-	?

Subunits

Subunits	Comment	Organism
homodimer	x-ray crystallography	Homo sapiens

Synonyms

Synonyms	Comment	Organism
CoaB	-	Homo sapiens
PPC synthetase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)