Literature summary for 6.3.2.43 extracted from

Montoya-Rosales, A.; Provvedi, R.; Torres-Juarez, F.; Enciso-Moreno, J.; Hernandez-Pando, R.; Manganelli, R.; Rivas-Santiago, B.
lysX gene is differentially expressed among Mycobacterium tuberculosis strains with different levels of virulence (2017), Tuberculosis, 106, 106-117 .

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Application

Application	Comment	Organism
medicine	in the presence of antimicrobial peptides produced by epithelial cells and macrophages, lysX expression increases significantly. Strains with higher lysX expression show increased levels of intracellular survival in vivo and in vitro and induce more severe lesion related with pneumonia. The ability of Mycobacterium tuberculosis to replicate intracellularly is directly correlated to the level of lysX expression	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	-	-	-
Mycobacterium tuberculosis	A5U2Z7	-	-
Mycobacterium tuberculosis	P9WFU7	-	-
Mycobacterium tuberculosis H37Rv	P9WFU7	-	-
Mycobacterium tuberculosis LAM09005186	-	-	-

Synonyms

Synonyms	Comment	Organism
LysX	-	Mycobacterium tuberculosis

Expression

Organism	Comment	Expression
Mycobacterium tuberculosis	in the presence of antimicrobial peptides, lysX expression increases significantly	up

General Information

General Information	Comment	Organism
physiological function	in the presence of antimicrobial peptides produced by epithelial cells and macrophages, lysX expression increases significantly. Strains with higher lysX expression show increased levels of intracellular survival in vivo and in vitro and induce more severe lesion related with pneumonia. The ability of Mycobacterium tuberculosis to replicate intracellularly is directly correlated to the level of lysX expression	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)