Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.3.2.4 extracted from

  • Azam, S.; Abbasi, S.; Akhtar, A.; Mirza, M.
    Comparative modeling and molecular docking studies of D-alanine D-alanine ligase a target of antibacterial drugs (2014), Med. Chem. Res., 23, 4108-4137 .
No PubMed abstract available
Search for more literature for 6.3.2.4

Cloned(Commentary)

Cloned (Comment) Organism
gene ddl, recombinant expression Streptococcus sanguinis

Inhibitors

Inhibitors Comment Organism Structure
(1E,3Z)-N-(2-carbamimidamidoethyl)-4-(pyridin-3-yl)buta-1,3-diene-1-sulfonamide
-
 Streptococcus sanguinis
(2-aminoethyl)phosphonic acid
-
 Streptococcus sanguinis
(2E)-3-amino-2-[(E)-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-3-sulfanylprop-2-enenitrile
-
 Streptococcus sanguinis
(2R)-2-aminopropanoyl hydrogen (2-hydroxybutanoyl)phosphonate
-
 Streptococcus sanguinis
(2R)-2-[[(1-aminoethyl)(hydroxy)phosphoryl]methyl]nonanoic acid
-
 Streptococcus sanguinis
(2S)-2-amino-4-[(3S)-3-hydroxy-2-oxoazetidin-3-yl]butanoic acid
-
 Streptococcus sanguinis
(2Z)-2-cyano-3-hydroxy-N-(2,4,6-trimethylphenyl)but-2-enamide
-
 Streptococcus sanguinis
(2Z)-2-cyano-3-hydroxy-N-[2-methyl-3,6-bis(trifluoromethyl)phenyl]but-2-enamide
-
 Streptococcus sanguinis
(2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethoxy)phenyl]but-2-enamide
-
 Streptococcus sanguinis
(2Z)-2-cyano-N-(2,5-dibromophenyl)-3-hydroxybut-2-enamide
-
 Streptococcus sanguinis
(2Z)-2-cyano-N-(2,6-dimethylphenyl)-3-hydroxybut-2-enamide
-
 Streptococcus sanguinis
(2Z)-N-(2-chloro-6-methylphenyl)-2-cyano-3-hydroxybut-2-enamide
-
 Streptococcus sanguinis
(2Z)-N-(2-chloro-6-methylphenyl)-2-ethynyl-3-hydroxybut-2-enamide
-
 Streptococcus sanguinis
(3Z)-4-cyano-5-(3,6-dibromo-2-methylanilino)-3-hydroxy-5-oxopent-3-enoic acid
-
 Streptococcus sanguinis
(4R)-4-amino-1,2-oxazolidin-3-one
-
 Streptococcus sanguinis
(E)-2-[[(chloromethyl)amino]acetyl]-N-[(pyridin-2-yl)methyl]diazene-1-carboxamide
-
 Streptococcus sanguinis
(E)-N1,N2-bis(2-chloroethyl)diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
(E)-N1,N2-bis[(pyridin-3-yl)methyl]diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
(E)-N1-(2-chloroethyl)-N2-(4-methylphenyl)diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
(E)-N1-(2-chloroethyl)-N2-[(pyridin-4-yl)methyl]diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
(E)-N1-(3-chlorophenyl)-N2-[(pyridin-3-yl)methyl]diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
(E)-N1-(3-chlorophenyl)-N2-[(pyridin-4-yl)methyl]diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
(E)-N1-(4-fluorophenyl)-N2-[(pyridin-4-yl)methyl]diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
(E)-N1-cyclohexyl-N2-[(pyridin-2-yl)methyl]diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
(E)-N1-cyclohexyl-N2-[(pyridin-4-yl)methyl]diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
(E)-N1-phenyl-N2-[(pyridin-3-yl)methyl]diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
(E)-N1-phenyl-N2-[(pyridin-4-yl)methyl]diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
(E)-N1-[4-(butan-2-yl)phenyl]-N2-(2-chloroethyl)diazene-1,2-dicarboxamide
-
 Streptococcus sanguinis
1-[(4-fluorocyclohexane-1-sulfonyl)amino]-3-(morpholin-4-yl)propan-2-yl dihydrogen phosphate
-
 Streptococcus sanguinis
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one
-
 Streptococcus sanguinis
2-(3-methylmorpholin-4-yl)-8-phenyl-2,3-dihydro-4H-1-benzopyran-4-one
-
 Streptococcus sanguinis
2-([(1R)-1-aminoethyl](hydroxy)phosphoryl]methyl)octanoic acid
-
 Streptococcus sanguinis
2-amino-4-(3,4,5-trihydroxyphenyl)but-1-ene-1,1,3-tricarbonitrile
-
 Streptococcus sanguinis
2-cyano-3-hydroxy-N-[2-methyl-4-(trifluoromethyl)phenyl]butanamide
-
 Streptococcus sanguinis
2-hydroxy-N-(2,4,6-trimethylphenyl)benzamide
-
 Streptococcus sanguinis
2-[[(1-aminoethyl)(hydroxy)phosphoryl]methyl]nonanoic acid
-
 Streptococcus sanguinis
2-[[6-(benzylamino)-9-methyl-9H-purin-2-yl]amino]ethan-1-ol
-
 Streptococcus sanguinis
3-chloro-2,2-dimethyl-N-[4-(trifluoromethyl)cyclohexyl]propanamide
-
 Streptococcus sanguinis
3-[[(1S)-1-aminoethyl](hydroxy)phosphoryl]-2-methylpropanoic acid
-
 Streptococcus sanguinis
4-chloro-3,3-dimethyl-N-[4-(trifluoromethyl)phenyl]butanamide
-
 Streptococcus sanguinis
4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol
-
 Streptococcus sanguinis
5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
-
 Streptococcus sanguinis
5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
-
 Streptococcus sanguinis
6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6-(2,6-dichlorophenyl)-N2-[3-(dimethylamino)propyl]pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6-(2,6-dichlorophenyl)-N2-[3-(morpholin-4-yl)propyl]pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6-(2,6-difluorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6-(2-chloro-6-fluorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6-(3,5-dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6-(3,5-dimethoxyphenyl)-N2-[3-(morpholin-4-yl)propyl]pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6-(3,5-dimethylphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6-phenylpyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
6-[3,5-bis(trifluoromethyl)phenyl]pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
D-alanyl-D-alanine
-
 Streptococcus sanguinis
glycine
-
 Streptococcus sanguinis
glycylglycine
-
 Streptococcus sanguinis
additional information inhibitor docking and molecular structure modeling, overview Streptococcus sanguinis
N-(2,5-dibromophenyl)-2-oxopropanamide
-
 Streptococcus sanguinis
N-(2,6-dimethylphenyl)-2-hydroxybenzamide
-
 Streptococcus sanguinis
N-(2-amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl)-N'-tert-butylurea
-
 Streptococcus sanguinis
N-(3,6-dibromo-2-methylphenyl)-2-hydroxybenzamide
-
 Streptococcus sanguinis
N-tert-butyl-N'-[6-(2,6-dichlorophenyl)-2-[[3-(morpholin-4-yl)propyl]amino]pyrido[2,3-d]pyrimidin-7-yl]urea
-
 Streptococcus sanguinis
N-tert-butyl-N'-[6-(3,5-dimethoxyphenyl)-2-[[3-(morpholin-4-yl)propyl]amino]pyrido[2,3-d]pyrimidin-7-yl]urea
-
 Streptococcus sanguinis
N-[(2S)-1-[(dihydroxyphosphanyl)oxy]-1-oxopropan-2-yl]-D-alaninamide
-
 Streptococcus sanguinis
N-[2-amino-6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-tert-butylurea
-
 Streptococcus sanguinis
N-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-tert-butylurea
-
 Streptococcus sanguinis
N-[2-amino-6-(2,6-difluorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-tert-butylurea
-
 Streptococcus sanguinis
N-[2-amino-6-(2-chloro-6-fluorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-tert-butylurea
-
 Streptococcus sanguinis
N-[2-amino-6-(3,5-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-tert-butylurea
-
 Streptococcus sanguinis
N-[2-amino-6-(3,5-difluorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-tert-butylurea
-
 Streptococcus sanguinis
N-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-tert-butylurea
-
 Streptococcus sanguinis
N-[2-amino-6-[3,5-bis(trifluoromethyl)phenyl]pyrido[2,3-d]pyrimidin-7-yl]-N'-tert-butylurea
-
 Streptococcus sanguinis
N2-(3-aminopropyl)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidine-2,7-diamine
-
 Streptococcus sanguinis
P-(aminomethyl)phosphonamidic acid
-
 Streptococcus sanguinis
[(1R)-1-aminoethyl]phosphinic acid
-
 Streptococcus sanguinis
[(1R)-1-aminoethyl]phosphonic acid
-
 Streptococcus sanguinis

Organism

Organism UniProt Comment Textmining
Streptococcus sanguinis A3CLS3
-
-
Streptococcus sanguinis SK36 A3CLS3
-
-

Subunits

Subunits Comment Organism
More three-dimensional enzyme structure and structure homology modeling using the Ddl structure mdoel of Streptococcus mutans (SmDdl) as template, PDB ID 3K3P, overview Streptococcus sanguinis

Synonyms

Synonyms Comment Organism
D-Alanine:D-alanine ligase
-
 Streptococcus sanguinis
Ddl
-
 Streptococcus sanguinis
SsDdl
-
 Streptococcus sanguinis

General Information

General Information Comment Organism
additional information comparative molecular modeling approach for SsDdl, enzyme structure homology modeling using the Ddl structure mdoel of Streptococcus mutans (SmDdl) as template, PDB ID 3K3P, overview Streptococcus sanguinis