Inhibitors | Comment | Organism | Structure |
---|---|---|---|
apigenin | 4',5,7-trihydroxyflavone, inhibition mechanism, competitive with respect to the substrate ATP and non-competitive to the substrate D-Ala | Escherichia coli | |
apigenin | 4',5,7-trihydroxyflavone, inhibition mechanism, competitive with respect to the substrate ATP and non-competitive to the substrate D-Ala | Helicobacter pylori | |
quercetin | i.e. 3,3',4',5,7-pentahydroxyflavone, inhibition mechanism, competitive with respect to the substrate ATP and non-competitive to the substrate D-Ala | Escherichia coli | |
quercetin | i.e. 3,3',4',5,7-pentahydroxyflavone, inhibition mechanism, competitive with respect to the substrate ATP and non-competitive to the substrate D-Ala | Helicobacter pylori |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetic analysis | Escherichia coli | |
additional information | - |
additional information | kinetic analysis | Helicobacter pylori |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Escherichia coli | |
Mg2+ | - |
Helicobacter pylori |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-alanine | Escherichia coli | - |
ADP + phosphate + D-alanyl-D-alanine | - |
? | |
ATP + D-alanine | Helicobacter pylori | - |
ADP + phosphate + D-alanyl-D-alanine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
strains BL21(DE3) and JM109 | - |
Helicobacter pylori | - |
strains SS1 and ATCC 43504, ddl gene | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-alanine | - |
Escherichia coli | ADP + phosphate + D-alanyl-D-alanine | - |
? | |
ATP + D-alanine | - |
Helicobacter pylori | ADP + phosphate + D-alanyl-D-alanine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
D-Alanine:D-alanine ligase | - |
Escherichia coli |
D-Alanine:D-alanine ligase | - |
Helicobacter pylori |
Ddl | - |
Helicobacter pylori |
DdlB | - |
Escherichia coli |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Escherichia coli |
25 | - |
assay at | Helicobacter pylori |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Escherichia coli |
7.4 | - |
assay at | Helicobacter pylori |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Escherichia coli | |
ATP | - |
Helicobacter pylori |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics | Helicobacter pylori | |
additional information | - |
additional information | inhibition kinetics at pH 7.4 and 25°C | Escherichia coli | |
0.0043 | - |
quercetin | pH 7.4, 25°C, versus ATP | Helicobacter pylori | |
0.0097 | - |
quercetin | pH 7.4, 25°C, versus ATP | Escherichia coli | |
0.0101 | - |
quercetin | pH 7.4, 25°C, versus D-Ala | Escherichia coli | |
0.028 | - |
quercetin | pH 7.4, 25°C, versus D-Ala | Helicobacter pylori | |
0.031 | - |
apigenin | pH 7.4, 25°C, versus ATP | Helicobacter pylori | |
0.0807 | - |
apigenin | pH 7.4, 25°C, versus ATP | Escherichia coli | |
0.085 | - |
apigenin | pH 7.4, 25°C, versus D-Ala | Helicobacter pylori | |
0.1195 | - |
apigenin | pH 7.4, 25°C, versus D-Ala | Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0199 | - |
pH 7.4, 25°C | Escherichia coli | quercetin | |
0.0485 | - |
pH 7.4, 25°C | Helicobacter pylori | quercetin | |
0.1327 | - |
pH 7.4, 25°C | Helicobacter pylori | apigenin | |
0.163 | - |
pH 7.4, 25°C | Escherichia coli | apigenin |