Activating Compound | Comment | Organism | Structure |
---|---|---|---|
A771726 | a leflunomide metabolite, slightly activating | Escherichia coli | |
N-(2,5-dibromophenyl)-2-oxopropanamide | slightly activating | Escherichia coli |
Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a target for antibiotic inhibitor development, overview | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2Z)-N-(2-chloro-6-methylphenyl)-2-ethynyl-3-hydroxybut-2-enamide | - |
Escherichia coli | |
D-cycloserine | competitive inhibitor | Escherichia coli | |
diazenocarboxamide | - |
Escherichia coli | |
H-1004 | slight inhibition | Escherichia coli | |
leflunomide | an antirheumatic drug | Escherichia coli | |
LFM-A12 | an analog of the Leflunomide metabolite A771726 | Escherichia coli | |
LFM-A13 | Brutons's tyrosine kinase inhibitor, an analog of the Leflunomide metabolite A771726 | Escherichia coli | |
LY294002 | slight inhibition | Escherichia coli | |
additional information | antibiotic inhibitor design, bisubstrate inhibitors that block the ATP and D-Ala binding sites exhibit enhanced selectivity and potency profiles by preferentially inhibiting DDl over kinases, overview | Escherichia coli | |
N-(2,5-dibromophenyl)-2-oxopropanamide | - |
Escherichia coli | |
Olomoucine | - |
Escherichia coli | |
piceatannol | slight inhibition | Escherichia coli | |
quercetin | - |
Escherichia coli | |
tyrphostin 47 | competitive versus ATP | Escherichia coli | |
tyrphostin 51 | mixed-type inhibition | Escherichia coli | |
Wortmannin | slight inhibition | Escherichia coli | |
[3-chloro-2,2-dimethyl-N-4(trimethylfluoro)phenyl]propanamide | - |
Escherichia coli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-alanine | Escherichia coli | - |
ADP + phosphate + D-alanyl-D-alanine | - |
? | |
additional information | Escherichia coli | DDl is an essential enzyme in bacterial cell wall biosynthesis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P07862 | two isoforms of DDl, DDlA and DDlB | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-alanine | - |
Escherichia coli | ADP + phosphate + D-alanyl-D-alanine | - |
? | |
additional information | DDl is an essential enzyme in bacterial cell wall biosynthesis | Escherichia coli | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DD1 | - |
Escherichia coli |
DDI | - |
Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.185 | - |
D-cycloserine | - |
Escherichia coli | |
0.185 | - |
LFM-A13 | - |
Escherichia coli | |
0.215 | - |
N-(2,5-dibromophenyl)-2-oxopropanamide | - |
Escherichia coli | |
0.29 | - |
tyrphostin 47 | - |
Escherichia coli | |
1.4 | - |
LY294002 | - |
Escherichia coli | |
1.8 | - |
Olomoucine | - |
Escherichia coli |