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Literature summary for 6.3.2.36 extracted from

  • Yokooji, Y.; Tomita, H.; Atomi, H.; Imanaka, T.
    Pantoate kinase and phosphopantothenate synthetase, two novel enzymes necessary for CoA biosynthesis in the archaea (2009), J. Biol. Chem., 284, 28137-28145.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.2.36

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Thermococcus kodakarensis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
29843
-
 2 * 29843, calculated from sequence Thermococcus kodakarensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 4-phosphopantoate + beta-alanine Thermococcus kodakarensis the pantoate kinase/phosphopantothenate synthetase system represents the pathway for 4'-phosphopantothenate biosynthesis in Thermococcus kodakaraensis. The enzymes are necessary for CoA biosynthesis in this organism AMP + diphosphate + 4'-phosphopantothenate
-
 ?

Organism

Organism UniProt Comment Textmining
Thermococcus kodakarensis Q5JIZ8
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Thermococcus kodakarensis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 4-phosphopantoate + beta-alanine
-
 Thermococcus kodakarensis AMP + diphosphate + 4'-phosphopantothenate
-
 ?
ATP + 4-phosphopantoate + beta-alanine the pantoate kinase/phosphopantothenate synthetase system represents the pathway for 4'-phosphopantothenate biosynthesis in Thermococcus kodakaraensis. The enzymes are necessary for CoA biosynthesis in this organism Thermococcus kodakarensis AMP + diphosphate + 4'-phosphopantothenate
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 29843, calculated from sequence Thermococcus kodakarensis

Synonyms

Synonyms Comment Organism
phosphopantothenate synthetase
-
 Thermococcus kodakarensis
Pps
-
 Thermococcus kodakarensis
TK1686 protein
-
 Thermococcus kodakarensis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Thermococcus kodakarensis

General Information

General Information Comment Organism
malfunction the deletion mutant strain grows well in media supplemented with 1 mM CoA. The deletion mutant strain can not grow at all in the absence of CoA Thermococcus kodakarensis