Any feedback?
Literature summary for 6.3.2.3 extracted from
- Investigating arsenic susceptibility from a genetic perspective in Drosophila reveals a key role for glutathione synthetase (2008), Toxicol. Sci., 107, 416-426.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| GS gene, located at chromosome 16F1, mapping of an X-linked arsenite-tolerance component to subdivision 16, overview | Drosophila melanogaster |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | creation of targeted X chromosomal deficiency lines. Relative arsenite sensitivity arises when the dose of the glutathione synthetase gene expression is reduced by half. Knockdown of GS expression by RNAi in cultured S2 cells leads to enhanced arsenite sensitivity, while GS RNAi applied to intact organisms dramatically reduces the concentration of food-borne arsenite compatible with successful growth and development, phenotypes, overview | Drosophila melanogaster |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Drosophila melanogaster |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + gamma-L-glutamyl-L-cysteine + glycine | Drosophila melanogaster | an optimally functioning two-step glutathione biosynthetic pathway is required in vivo for a robust defense against arsenite | ADP + phosphate + glutathione | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + gamma-L-glutamyl-L-cysteine + glycine | - |
Drosophila melanogaster | ADP + phosphate + glutathione | - |
? | |
| ATP + gamma-L-glutamyl-L-cysteine + glycine | an optimally functioning two-step glutathione biosynthetic pathway is required in vivo for a robust defense against arsenite | Drosophila melanogaster | ADP + phosphate + glutathione | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Glutathione synthetase | - |
Drosophila melanogaster |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Drosophila melanogaster | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
