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Literature summary for 6.3.2.3 extracted from

  • Du, T.; Ciccotosto, G.D.; Cranston, G.A.; Kocak, G.; Masters, C.L.; Crouch, P.J.; Cappai, R.; White, A.R.
    Neurotoxicity from glutathione depletion is mediated by Cu-dependent p53 activation (2008), Free Radic. Biol. Med., 44, 44-55.
    View publication on PubMed
Search for more literature for 6.3.2.3

Inhibitors

Inhibitors Comment Organism Structure
buthionine sulfoximine
-
 Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + gamma-L-glutamyl-L-cysteine + glycine Mus musculus the enzyme catalyzes the last step in glutathione biosynthesis, loss of intracellular neuronal GSH is an important feature of neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, overview ADP + phosphate + glutathione
-
 ?
additional information Mus musculus the consequences of GSH depletion include increased oxidative damage to proteins, lipids, and DNA and subsequent cytotoxic effects. GSH is also an important modulator of cellular copper homeostasis and altered Cu metabolism is central to the pathology of several neurodegenerative diseases. Both neurons and fibroblasts revealed increased expression and activation of p53 after depletion of GSH ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Mus musculus
-
neuron primary cortical neurons Mus musculus
-
NIH-3T3 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + gamma-L-glutamyl-L-cysteine + glycine
-
 Mus musculus ADP + phosphate + glutathione
-
 ?
ATP + gamma-L-glutamyl-L-cysteine + glycine the enzyme catalyzes the last step in glutathione biosynthesis, loss of intracellular neuronal GSH is an important feature of neurodegenerative disorders including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, overview Mus musculus ADP + phosphate + glutathione
-
 ?
additional information the consequences of GSH depletion include increased oxidative damage to proteins, lipids, and DNA and subsequent cytotoxic effects. GSH is also an important modulator of cellular copper homeostasis and altered Cu metabolism is central to the pathology of several neurodegenerative diseases. Both neurons and fibroblasts revealed increased expression and activation of p53 after depletion of GSH Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
Glutathione synthetase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus