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Literature summary for 6.3.2.3 extracted from

  • Tchantchou, F.; Graves, M.; Ashline, D.; Morin, A.; Pimenta, A.; Ortiz, D.; Rogers, E.; Shea, T.B.
    Increased transcription and activity of glutathione synthase in response to deficiencies in folate, vitamin E, and apolipoprotein E (2004), J. Neurosci. Res., 75, 508-515.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information folate and vitamin E depletion leads to 18% increased enzyme expression and activity, mice mutants lacking apolipoprotein E show even higher activation rates of 31% on minimal diet compared to the wild-type on normal diet Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information ApoE-deficient mice show reduced enzyme expression and activity Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + gamma-L-Glu-L-Cys + Gly Mus musculus ApoE-deficient mice show reduced enzyme expression and activity, genetic regulation mechanism, overview ADP + phosphate + glutathione
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
normal and ApoE-/- mice
-

Purification (Commentary)

Purification (Comment) Organism
partial from brain Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3 8 about, wild-type mice on minimal diet Mus musculus
32
-
about, ApoE-deficient mice on normal diet Mus musculus
33.5
-
about, wild-type mice on normal diet Mus musculus
43
-
about, ApoE-deficient mice on minimal diet Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + gamma-L-Glu-L-Cys + Gly
-
Mus musculus ADP + phosphate + glutathione
-
?
ATP + gamma-L-Glu-L-Cys + Gly ApoE-deficient mice show reduced enzyme expression and activity, genetic regulation mechanism, overview Mus musculus ADP + phosphate + glutathione
-
?

Synonyms

Synonyms Comment Organism
GS
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus