Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | folate and vitamin E depletion leads to 18% increased enzyme expression and activity, mice mutants lacking apolipoprotein E show even higher activation rates of 31% on minimal diet compared to the wild-type on normal diet | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | ApoE-deficient mice show reduced enzyme expression and activity | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + gamma-L-Glu-L-Cys + Gly | Mus musculus | ApoE-deficient mice show reduced enzyme expression and activity, genetic regulation mechanism, overview | ADP + phosphate + glutathione | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
normal and ApoE-/- mice | - |
Purification (Comment) | Organism |
---|---|
partial from brain | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
3 | 8 | about, wild-type mice on minimal diet | Mus musculus |
32 | - |
about, ApoE-deficient mice on normal diet | Mus musculus |
33.5 | - |
about, wild-type mice on normal diet | Mus musculus |
43 | - |
about, ApoE-deficient mice on minimal diet | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + gamma-L-Glu-L-Cys + Gly | - |
Mus musculus | ADP + phosphate + glutathione | - |
? | |
ATP + gamma-L-Glu-L-Cys + Gly | ApoE-deficient mice show reduced enzyme expression and activity, genetic regulation mechanism, overview | Mus musculus | ADP + phosphate + glutathione | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GS | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |