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Literature summary for 6.3.2.3 extracted from
- Glutathione synthesis (1974), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 10, 671-697.
No PubMed abstract available
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.083 | - |
ATP | reaction with Glu-alpha-aminobutyrate + hydroxylamine | Saccharomyces cerevisiae |  |
| 0.2 | - |
gamma-Glu-Cys | - |
Homo sapiens | |
| 0.36 | - |
Gly | - |
Homo sapiens | |
| 0.5 | - |
gamma-Glu-2-aminobutyrate | - |
Saccharomyces cerevisiae | |
| 0.5 | - |
gamma-Glu-2-aminobutyrate | ATP | Homo sapiens | |
| 0.8 | - |
Gly | hydroxylamine | Saccharomyces cerevisiae | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60000 | - |
2 * 60000, SDS-PAGE | Saccharomyces cerevisiae |
| 122000 | 123000 | gel filtration | Saccharomyces cerevisiae |
| 122000 | 123000 | meniscus depletion method | Saccharomyces cerevisiae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Pigeon | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
| liver | - |
Pigeon | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + gamma-Glu-2-aminobutyrate + hydroxylamine | - |
Homo sapiens | ADP + phosphate + gamma-(alpha-aminomethyl)Glu-2-aminobutyryl-Gly | - |
? | |
| ATP + gamma-Glu-2-aminobutyrate + hydroxylamine | - |
Saccharomyces cerevisiae | ADP + phosphate + gamma-(alpha-aminomethyl)Glu-2-aminobutyryl-Gly | - |
? | |
| ATP + gamma-Glu-aminobutyrate + Gly | - |
Saccharomyces cerevisiae | ADP + phosphate + ophthalmic acid | - |
? | |
| ATP + gamma-Glu-L-Cys + aminomethanesulfonic acid | - |
Pigeon | ADP + phosphate + gamma-Glu-L-Cys-aminomethanesulfonic acid | - |
? | |
| ATP + gamma-Glu-L-Cys + Gly | - |
Escherichia coli | ADP + phosphate + glutathione | - |
? | |
| ATP + gamma-Glu-L-Cys + Gly | - |
Homo sapiens | ADP + phosphate + glutathione | - |
? | |
| ATP + gamma-Glu-L-Cys + Gly | - |
Saccharomyces cerevisiae | ADP + phosphate + glutathione | - |
? | |
| ATP + gamma-Glu-L-Cys + Gly | - |
Pigeon | ADP + phosphate + glutathione | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Homo sapiens |
| dimer | 2 * 60000, SDS-PAGE | Saccharomyces cerevisiae |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 58 | - |
relatively stable in presence of 25 mM glutathione | Saccharomyces cerevisiae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | 8 | - |
Homo sapiens |
| 7.5 | 9 | - |
Saccharomyces cerevisiae |
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