Literature summary for 6.3.2.25 extracted from

Dal Piaz, F.; Vassallo, A.; Lepore, L.; Tosco, A.; Bader, A.; De Tommasi, N.
Sesterterpenes as tubulin tyrosine ligase inhibitors. First insight of structure-activity relationships and discovery of new lead (2009), J. Med. Chem., 52, 3814-3828.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(1R,4aS,6R,8S)-6,8-dihydroxy-5-[(3E)-5-hydroxy-5-(3-hydroxy-5-oxo-2,5-dihydrofuran-2-yl)-3-methylpent-3-en-1-yl]-4a,6-dimethyldecahydronaphthalene-1-carboxylic acid	increases the non-tyrosinatable form of alpha-tubulin in human cancer cell cultures indicating to act as an inhibitor of TTL	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
45000	-	loaded with binding partners, mass spectrometry	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
TTL	-	Homo sapiens
tubulin tyrosine ligase	-	Homo sapiens

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Release 2023.1 (January 2023)