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Literature summary for 6.3.2.2 extracted from

  • Ferguson, G.; Bridge, W.
    Glutamate cysteine ligase and the age-related decline in cellular glutathione the therapeutic potential of gamma-glutamylcysteine (2016), Arch. Biochem. Biophys., 593, 12-23 .
    View publication on PubMed
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Application

Application Comment Organism
medicine suitability of treatment of humans with exogenous enzyme gamma-GC to raise GSH levels by circumventing the age-related dysregulation of the rate-limiting step of GSH, providing promise for future research for the treatment of chronic oxidative stress-related diseases Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
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 Rattus norvegicus 5829
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus P19468 AND P48508 genes GCLC and GCLM encoding heavy and light chain subunits
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Subunits

Subunits Comment Organism
heterodimer enzyme GCL is a heterodi­meric enzyme consisting of a catalytic subunit (GCLc) and a modulatory subunit (GCLm), which are encoded by two genes Rattus norvegicus

Synonyms

Synonyms Comment Organism
gamma-GC
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 Rattus norvegicus
GCL
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 Rattus norvegicus
GCLC
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 Rattus norvegicus
GCLM
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 Rattus norvegicus
glutamate cysteine ligase
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 Rattus norvegicus

General Information

General Information Comment Organism
physiological function GSH is an essential thiol antioxidant produced in the cytosol of all cells and plays a key role in protecting against oxidative stress by neutralising free radicals and reactive oxygen species (ROS). The decline in GSH has been associated with changes in the expression and activity of the rate-limiting enzyme glutamate cysteine ligase (GCL), which produces the intermediate dipeptide gamma-glutamylcysteine. The molecular mechanisms that affect these age-related changes and the complexity of GCL regulation are analyzed. Impairment of the transcriptional activity of Nrf2 contributes to GCL dysregulation in aged rats Rattus norvegicus