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Literature summary for 6.3.2.2 extracted from

  • Tiitto, L.H.; Peltoniemi, M.J.; Kaarteenaho-Wiik, R.L.; Soini, Y.M.; Paakko, P.K.; Sormunen, R.T.; Kinnula, V.L.
    Cell-specific regulation of gamma-glutamylcysteine synthetase in human interstitial lung diseases (2004), Hum. Pathol., 35, 832-839.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
lung both subunits of gamma-GCS are most prominently expressed in bronchiolar epithelium and are expressed generally weakly in alveolar macrophages. In interstitial lung diseases, gamma-GCS is expressed especially in the alveolar and metaplastic alveolar epithelium but is low in the fibrotic areas. The regulation of gamma-GCS is complex, being differentially modulated by various cytokines and durations of exposure, and in various cell types in human lung. Potential mechanism for the low gamma-GCS levels in fibrotic lung diseases may include down-regulation of catalytically active subunit of gamma-GCS Homo sapiens
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Synonyms

Synonyms Comment Organism
gamma-GCS
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Homo sapiens
gamma-Glutamylcysteine synthetase
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Homo sapiens