Cloned (Comment) | Organism |
---|---|
DNA sequence determination and analysis, heterodimer of a catalytic subunit and a regulatory subunit, encoded by 2 genes: GLCLC for the catalytic subunit, and GLCLR for the regulatory subunit, GLCLC polymorphism and existence of 5 alleles as defined by the trinucleotide repeat, which exhibits a range of 4 to 10 uninterrupted repeat, genotyping for the repeat of 60 tumor cancer cell lines, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the genotype of GLCLC is associated with drug sensitivity or resistance, respectively, sensitivity of different genotypes to diverse drugs, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-Glu + L-Cys | Homo sapiens | first and rate limiting step in glutathione biosynthesis | ADP + phosphate + gamma-L-Glu-L-Cys | - |
? | |
additional information | Homo sapiens | the genotype of GLCLC is associated with drug sensitivity or resistance, respectively | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | genotyping of 60 tumor cell lines from diverse source tissues for the GLCLC trinuleotide repeat | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-Glu + L-Cys | - |
Homo sapiens | ADP + phosphate + gamma-L-Glu-L-Cys | - |
? | |
ATP + L-Glu + L-Cys | first and rate limiting step in glutathione biosynthesis | Homo sapiens | ADP + phosphate + gamma-L-Glu-L-Cys | - |
? | |
additional information | the genotype of GLCLC is associated with drug sensitivity or resistance, respectively | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | heterodimer of a catalytic subunit and a regulatory subunit, encoded by 2 genes | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
GCL | - |
Homo sapiens |
GLCLC | - |
Homo sapiens |
GLCLR | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |