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Literature summary for 6.3.2.2 extracted from

  • Lüersen, K.; Muller, S.; Hussein, A.; Liebau, E.; Walter, R.D.
    The gamma-glutamylcysteine synthetase of Onchocerca volvulus (2000), Mol. Biochem. Parasitol., 111, 243-251.
    View publication on PubMed

Application

Application Comment Organism
pharmacology the enzyme is a potential drug target Onchocerca volvulus

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, single copy gene, genomic structure Onchocerca volvulus

Inhibitors

Inhibitors Comment Organism Structure
cystamine irreversible Onchocerca volvulus
L-buthionine-R,S-sulfoximine i.e. BSO, specific, irreversible Onchocerca volvulus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information preliminary steady state kinetics Onchocerca volvulus
1.2
-
L-glutamate pH 8.0, 37°C Onchocerca volvulus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
74200
-
x * 74200, amino acid sequence calculation Onchocerca volvulus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-Glu + L-Cys Onchocerca volvulus first and rate-limiting step in the glutathione biosynthesis, important for maintenance of the intracellular thiol redox status and in detoxification processes ADP + phosphate + gamma-L-Glu-L-Cys
-
r

Organism

Organism UniProt Comment Textmining
Onchocerca volvulus Q9NFN6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-Glu + L-Cys
-
Onchocerca volvulus ADP + phosphate + gamma-L-Glu-L-Cys
-
r
ATP + L-Glu + L-Cys first and rate-limiting step in the glutathione biosynthesis, important for maintenance of the intracellular thiol redox status and in detoxification processes Onchocerca volvulus ADP + phosphate + gamma-L-Glu-L-Cys
-
r

Subunits

Subunits Comment Organism
? x * 74200, amino acid sequence calculation Onchocerca volvulus

Synonyms

Synonyms Comment Organism
gamma-GCS
-
Onchocerca volvulus
gamma-Glutamylcysteine synthetase
-
Onchocerca volvulus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Onchocerca volvulus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Onchocerca volvulus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Onchocerca volvulus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00013
-
L-buthionine-R,S-sulfoximine pH 8.0, 37°C Onchocerca volvulus
0.0039
-
cystamine pH 8.0, 37°C Onchocerca volvulus