Literature summary for 6.3.2.2 extracted from

Yip, B.; Rudolph, F.B.
The kinetic mechanism of rat kidney gamma-glutamylcysteine synthetase (1976), J. Biol. Chem., 251, 3563-3568.

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Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine	partially random mechanism in which ATP is the obligatory first substrate and both amino acids bind in a random order to the enzymeATP complex. Formation of the enzymesubstrate quarternary complex is necessary prior to release of products	Rattus norvegicus	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
kidney	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-Glu + L-Cys	-	Rattus norvegicus	ADP + phosphate + gamma-L-Glu-L-Cys	-	?

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Release 2023.1 (January 2023)