Cloned (Comment) | Organism |
---|---|
gene GRMZM2G393334, DNA and amino acid sequence determination and analysis, expression of the enzyme in FPGS-deficient met7 yeast rescues the yeast mutant phenotype | Zea mays |
Protein Variants | Comment | Organism |
---|---|---|
additional information | at least four of 10 Mu-induced bm4 mutant alleles contain a Mu insertion in the FPGS GRMZM2G393334 gene, PCR-based sequencing of Mu-tagging alleles, the enzyme expression is reduced in the brown midrib4 (bm4) mutant, bm4 encodes a functional FPGS, sequence analysis and quantitative RT-PCR expression analysis of bm4-Mu alleles | Zea mays |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Zea mays |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate | Zea mays | - |
ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Zea mays | K7VM84 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate | - |
Zea mays | ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
100194131 | - |
Zea mays |
Folylpolyglutamate synthase | - |
Zea mays |
FPGS | - |
Zea mays |
GRMZM2G393334 | - |
Zea mays |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Zea mays |
General Information | Comment | Organism |
---|---|---|
malfunction | the enzyme expression is reduced in the brown midrib4 (bm4) mutant, the mutation of gene bm4 affects the accumulation and composition of lignin in maize, phenotype, overview. bm4 mutants exhibit a modest decrease in lignin concentration and an overall increase in the S:G lignin ratio relative to wild-type. At least four of 10 Mu-induced bm4 mutant alleles contain a Mu insertion in the FPGS GRMZM2G393334 gene | Zea mays |
metabolism | folylpolyglutamate synthase (FPGS) functions in one-carbon (C1) metabolism and in lignin biosynthesis, lignin biosynthesispathway overview | Zea mays |
physiological function | folylpolyglutamate synthase (FPGS) functions in one-carbon (C1) metabolism to polyglutamylate substrates of folate-dependent enzymes. Role for FPGS in lignin biosynthesis | Zea mays |