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Literature summary for 6.3.2.17 extracted from
- Effect of the polymorphism of folylpolyglutamate synthetase on treatment of high-dose methotrexate in pediatric patients with acute lymphocytic leukemia (2016), Med. Sci. Monit., 22, 4967-4973 .
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | FPGS rs1544105 alleles are demonstrated to be an indicator for poor prognosis | Homo sapiens |
| pharmacology | polymorphism of FPGS rs1544105 might be used as an effective approach for prediction of the treatment outcome of methotrexate (MTX) | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene FPGS, genotyping of FPGS rs1544105 polymorphism in 57 ALL patients and 31 age and sex-matched children | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | genotyping of FPGS rs1544105 polymorphism in 57 ALL patients and 31 age and sex-matched children, overall survival is analyzed by Kaplan-Meier method. No differences are observed between patients and controls regarding the distribution frequency of genotype and alleles of rs1544105. Patients carrying AA genotype have a significantly higher plasma concentration of methotrexate after 24 h than those carrying GG or GA (P<0.05) and no differences are found after 44 h. Kaplan-Meier survival analysis shows a longer median survival time in patients with AA than other genotypes with significant difference in overall survival | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate | Homo sapiens | - |
ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| peripheral blood cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate | - |
Homo sapiens | ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Folylpolyglutamate synthetase | - |
Homo sapiens |
| FPGS | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | analysis of the association of folylpolyglutamate synthetase (FPGS) polymorphism with the dynamic plasma concentration of methotrexate (MTX) in pediatric patients with acute lymphocytic leukemia (ALL), overview. FPGS rs1544105 alleles are demonstrated to be an indicator for poor prognosis | Homo sapiens |
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