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Literature summary for 6.3.2.17 extracted from

  • Hashiguchi, M.; Tanaka, T.; Shimizu, M.; Tsuru, T.; Chiyoda, T.; Miyawaki, K.; Irie, S.; Takeuchi, O.; Hakamata, J.; Mochizuki, M.
    Sex differences in mRNA expression of reduced folate carrier-1, folypolyformyl glutamate synthase, and gamma-glutamyl hydrolase in a healthy Japanese population (2016), J. Clin. Pharm., 56, 1563-1569 .
    View publication on PubMed
Search for more literature for 6.3.2.17

Cloned(Commentary)

Cloned (Comment) Organism
gene fpgs, determination of genotypes and mRNA expression levels in 190 female and male unrelated healthy Japanese people, quantitative real-time PCR enzyme expression analysis reveals significant differences in sex-specific mRNA expression, detailed overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate Homo sapiens
-
 ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q05932
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information quantitative real-time PCR enzyme expression analysis reveals significant differences in sex-specific mRNA expression, detailed overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate
-
 Homo sapiens ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
-
 ?

Synonyms

Synonyms Comment Organism
folypolyformyl glutamate synthase
-
 Homo sapiens
FPGS
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function reduced folate carrier-1 (RFC-1), folypolyformyl glutamate synthase (FPGS), and gamma-glutamyl hydrolase (GGH) are important transporters and enzymes that convert methotrexate (MTX) in the body. Significant differences between men and women are observed in RFC-1, FPGS, and GGH mRNA expression in the Japanese population. The mRNA expression of FPGS and GGH is greater in women than that in men, but the expression of RFC-1 is less in the former than the latter. The relationship between genetic polymorphisms and mRNA expression including sex differences might contribute to the variation in the efficacy/toxicity of MTX in patients with rheumatoid arthritis Homo sapiens