Literature summary for 6.3.2.17 extracted from

Piwkham, D.; Siriboonpiputtana, T.; Beuten, J.; Pakakasama, S.; Gelfond, J.A.; Paisooksantivatana, K.; Tomlinson, G.E.; Rerkamnuaychoke, B.
Mutation screening and association study of the folylpolyglutamate synthetase (FPGS) gene with susceptibility to childhood acute lymphoblastic leukemia (2015), Asian Pac. J. Cancer Prev., 16, 4727-4732 .

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Cloned(Commentary)

Cloned (Comment)	Organism
gene FPGS, genotyping of 134 children suffering acute lymphoblastic leukemia (ALL), overview	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q05932	-	-

Synonyms

Synonyms	Comment	Organism
Folylpolyglutamate synthetase	-	Homo sapiens
FPGS	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	loss of FPGS activity results in decreased cellular levels of antifolates and consequently to polyglutamatable antifolates in acute lymphoblastic leukemia (ALL). Common genetic polymorphisms in the FPGS coding region including rs7039789, rs1544105, and rs10106 are significantly associated with increased ALL risk in Thai children	Homo sapiens
physiological function	folylpolyglutamate synthetase (FPGS) is an important enzyme in the folate metabolic pathway and plays a central role in intracellular accumulation of folate and antifolate in several mammalian cell types	Homo sapiens

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Release 2023.1 (January 2023)