Literature summary for 6.3.2.17 extracted from

Nagai, S.; Takenaka, K.; Sonobe, M.; Wada, H.; Tanaka, F.
Schedule-dependent synergistic effect of pemetrexed combined with gemcitabine against malignant pleural mesothelioma and non-small cell lung cancer cell lines (2008), Chemotherapy, 54, 166-175.

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Activating Compound

Activating Compound	Comment	Organism	Structure
pemetrexed	treatment of 211-H cells results in significantly higher expression of foloylpolyglutamate synthase and reduced folate carrier 1. Pemetrexed shows potent cytotoxicity in 211-H cells	Homo sapiens

Application

Application	Comment	Organism
medicine	pemetrexed shows potent cytotoxicity in 211-H cells compared to A-549 cells and H-1299 cells, accompanied by significantly higher expression of foloylpolyglutamate synthase and reduced folate carrier 1. Simulltaneous exposure of pemtrexed and gemcitabine is antagonistic in all cell lines tested, while strong synergism is observed in 211-H cells when pemetrexed precedes gemcitabine	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
MSTO-211H cell	-	Homo sapiens	-
NCI-H1299 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)