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Literature summary for 6.3.2.17 extracted from

  • Young, P.G.; Smith, C.A.; Metcalf, P.; Baker, E.N.
    Structures of Mycobacterium tuberculosis folylpolyglutamate synthase complexed with ADP and AMPPCP (2008), Acta Crystallogr. Sect. D, D64, 745-753.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with ADP and with adenylyl 5'-(beta,gamma-ethylene)diphosphonate at 2.0 and 2.3 A resolution, respectively. The nucleotide-binding site is deeply buried, while the binding of folate substrates occurs in a long extended groove. The active site beta5-alpha6-loop adopts an open position Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis O53174
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