Literature summary for 6.3.2.17 extracted from

Sakamoto, E.; Tsukioka, S.; Oie, S.; Kobunai, T.; Tsujimoto, H.; Sakamoto, K.; Okayama, Y.; Sugimoto, Y.; Oka, T.; Fukushima, M.; Oka, T.
Folylpolyglutamate synthase and gamma-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity (2007), Biochem. Biophys. Res. Commun., 365, 801-807.

Search for more literature for 6.3.2.17

Application

Application	Comment	Organism
medicine	siRNA transfected into DLD-1 cells to downregulate folylpolyglutamate synthase reduces the basal level of reduced folate, the folate level after leucovorin treatment, and the enhancement of 5-fluoro-2'-deoxyuridine-induced cytotoxicity elicited by leucovorin. Folylpolyglutamate synthase and gamma-glutamyl hydrolase expression levels in tumors are determinants of the efficacy of leucovorin in enhancing the antitumor activity of 5-fluorouracil	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Mus musculus	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	siRNA transfected into DLD-1 cells to downregulate folylpolyglutamate synthase reduces the basal level of reduced folate, the folate level after leucovorin treatment, and the enhancement of 5-fluoro-2'-deoxyuridine-induced cytotoxicity elicited by leucovorin. Folylpolyglutamate synthase and gamma-glutamyl hydrolase expression levels in tumors are determinants of the efficacy of leucovorin in enhancing the antitumor activity of 5-fluorouracil	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
COL-1 cell	-	Homo sapiens	-
colonic cancer cell	-	Homo sapiens	-
DLD-1 cell	-	Homo sapiens	-
HT-29 cell	-	Homo sapiens	-
KM-12C cell	-	Homo sapiens	-
KM-20C cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
Folylpolyglutamate synthase	-	Homo sapiens
FPGS	-	Homo sapiens

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Release 2023.1 (January 2023)