Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-(N-phosphonoacetyl)amino-2-L-(N-pteroylamino)propanoic acid | slight inhibition at 0.1 mM | Mus musculus | |
3-N-(methoxyphosphono)acetylamino-2-L-(N-pteroylamino)propanoic acid | slight inhibition at 0.1 mM | Mus musculus | |
4-amino-4-deoxypteroyl-L-ornithine | - |
Mus musculus | |
Nalpha-(4-amino-4-deoxy-5,8-diazapteroyl)-L-ornithine | - |
Mus musculus | |
Nalpha-(4-amino-4-deoxy-5,chloropteroyl)-L-ornithine | - |
Sus scrofa | |
Nalpha-(4-amino-4-deoxy-8-deazapteroyl)-L-ornithine | - |
Mus musculus | |
Nalpha-(4-amino-4-deoxy-N10-methylpteroyl)-Nepsilon-(phosphonoacetyl)-L-lysine | slight inhibition at 0.1 mM | Mus musculus | |
Nalpha-(5,8-dideaza-5-chloropteroyl)-L-ornithine | - |
Sus scrofa | |
Nalpha-(5,8-dideazapteroyl)-L-ornithine | - |
Mus musculus | |
Nalpha-pteroyl-L-ornithine | - |
Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.14 | - |
N-(p(((2-amino-4-hydroxy-6-pteridinyl)methyl)-amino)benzoyl)glutamic acid | - |
Mus musculus | |
0.14 | - |
N-(p(((2-amino-4-hydroxy-6-pteridinyl)methyl)-amino)benzoyl)glutamic acid | - |
Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | the enzyme catalyzes the consecutive addition of one or more L-glutamyl moieties to the gamma-carboxyl group in natural folates and glutamate-containing antifolates. Cells deficient in this enzyme are auxothrophic for thymidine and a purine | ? | - |
? | |
additional information | Sus scrofa | the enzyme catalyzes the consecutive addition of one or more L-glutamyl moieties to the gamma-carboxyl group in natural folates and glutamate-containing antifolates. Cells deficient in this enzyme are auxothrophic for thymidine and a purine | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
mouse | - |
Sus scrofa | - |
pig | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
liver | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 3-(N-phosphonoacetyl)amino-2-L-(N-pteroylamino)propanoic acid + L-glutamate | much less effective than folic acid | Mus musculus | ADP + 3-(N-phosphonoacetyl)amino-2-L-(N-pteroylamino)propanoyl-Glu + phosphate | - |
? | |
ATP + 3-N-(methoxyphosphono)acetylamino-2-L-(N-pteroylamino)propanoic acid + L-glutamate | much less effective than folic acid | Mus musculus | ADP + 3-N-(methoxyphosphono)acetylamino-2-L-(N-pteroylamino)propanoyl-Glu + phosphate | - |
? | |
ATP + 4-amino-4-deoxypteroyl-L-ornithine + L-glutamate | - |
Mus musculus | ? | - |
? | |
ATP + N-(p(((2-amino-4-hydroxy-6-pteridinyl)methyl)-amino)benzoyl)glutamic acid + L-glutamate | folic acid | Mus musculus | ADP + phosphate + N-(p(((2-amino-4-hydroxy-6-pteridinyl)methyl)-amino)benzoyl)-Glu2 | - |
? | |
ATP + N-(p(((2-amino-4-hydroxy-6-pteridinyl)methyl)-amino)benzoyl)glutamic acid + L-glutamate | folic acid | Sus scrofa | ADP + phosphate + N-(p(((2-amino-4-hydroxy-6-pteridinyl)methyl)-amino)benzoyl)-Glu2 | - |
? | |
ATP + Nalpha-(4-amino-4-deoxy-5,8-diazapteroyl)-L-ornithine + L-glutamate | - |
Mus musculus | ? | - |
? | |
ATP + Nalpha-(4-amino-4-deoxy-5,chloropteroyl)-L-ornithine + L-glutamate | - |
Sus scrofa | ? | - |
? | |
ATP + Nalpha-(4-amino-4-deoxy-8-deazapteroyl)-L-ornithine + L-glutamate | - |
Mus musculus | ? | - |
? | |
ATP + Nalpha-(4-amino-4-deoxy-N10-methylpteroyl)-Nepsilon-(phosphonoacetyl)-L-lysine + L-glutamate | much less effective than folic acid | Mus musculus | ? | - |
? | |
ATP + Nalpha-(5,8-dideaza-5-chloropteroyl)-L-ornithine + L-glutamate | - |
Sus scrofa | ? | - |
? | |
ATP + Nalpha-(5,8-dideazapteroyl)-L-ornithine + L-glutamate | - |
Mus musculus | ? | - |
? | |
ATP + Nalpha-pteroyl-L-ornithine + L-glutamate | - |
Mus musculus | ? | - |
? | |
additional information | the enzyme catalyzes the consecutive addition of one or more L-glutamyl moieties to the gamma-carboxyl group in natural folates and glutamate-containing antifolates. Cells deficient in this enzyme are auxothrophic for thymidine and a purine | Mus musculus | ? | - |
? | |
additional information | the enzyme catalyzes the consecutive addition of one or more L-glutamyl moieties to the gamma-carboxyl group in natural folates and glutamate-containing antifolates. Cells deficient in this enzyme are auxothrophic for thymidine and a purine | Sus scrofa | ? | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000017 | - |
Nalpha-(4-amino-4-deoxy-5,chloropteroyl)-L-ornithine | - |
Sus scrofa | |
0.0000083 | - |
Nalpha-(5,8-dideaza-5-chloropteroyl)-L-ornithine | - |
Sus scrofa | |
0.000018 | - |
Nalpha-(4-amino-4-deoxy-8-deazapteroyl)-L-ornithine | - |
Mus musculus | |
0.000072 | - |
Nalpha-(4-amino-4-deoxy-5,8-diazapteroyl)-L-ornithine | - |
Mus musculus | |
0.00015 | - |
4-amino-4-deoxypteroyl-L-ornithine | - |
Mus musculus | |
0.00035 | - |
Nalpha-(5,8-dideazapteroyl)-L-ornithine | - |
Mus musculus | |
0.0035 | - |
Nalpha-pteroyl-L-ornithine | - |
Mus musculus |