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Literature summary for 6.3.2.17 extracted from
- Purification and characterization of folylpolyglutamate synthetase (FPGS) from cultured cells of Datura innoxia (1997), J. Plant Physiol., 151, 528-534.
No PubMed abstract available
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 6.8 | - |
5,6,7,8-tetrahydropteroyl-Glu | - |
Datura inoxia |  |
| 35.7 | - |
ATP | - |
Datura inoxia | |
| 150 | - |
L-Glu | - |
Datura inoxia | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Datura inoxia | |
| Mg2+ | maximal activity at 20 mM | Datura inoxia | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 68000 | - |
gel filtration | Datura inoxia |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Datura inoxia | enzyme of folate biosynthetic pathway | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Datura inoxia | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Datura inoxia |
Storage Stability
| Storage Stability | Organism |
|---|---|
| stable at 0-4°C or at -20°C | Datura inoxia |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 5,6,7,8-tetrahydropteroyl-Glu + L-glutamate | - |
Datura inoxia | ADP + phosphate + 5,6,7,8-tetrahydropteroyl-Glu2 | - |
? | |
| ATP + 5,6,7,8-tetrahydropteroyl-Glun + Glu | n: 1 | Datura inoxia | ADP + phosphate + 5,6,7,8-tetrahydropteroyl-gamma-Glun+1 | - |
? | |
| ATP + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu | - |
Datura inoxia | ADP + phosphate + 5-formyl-5,6,7,8-tetrahydropteroyl-gamma-Glu2 | - |
? | |
| ATP + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun + Glu | n: 1 | Datura inoxia | ADP + phosphate + 5-methyl-5,6,7,8-tetrahydropteroyl-gamma-Glun+1 | - |
? | |
| ATP + 7,8-dihydropteroyl-Glun + Glu | n: 1 | Datura inoxia | ADP + phosphate + 7,8-dihydropteroyl-Glun+1 | - |
? | |
| ATP + methotrexate + Glu | - |
Datura inoxia | ADP + phosphate + methotrexyl-Glu | - |
? | |
| additional information | enzyme of folate biosynthetic pathway | Datura inoxia | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 68000, SDS-PAGE | Datura inoxia |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9.5 | - |
- |
Datura inoxia |
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