Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.3.2.17 extracted from

  • McGuire, J.J.; Bertino, J.R.
    Enzymatic synthesis and function of folylpolyglutamates (1981), Mol. Cell. Biochem., 38, 19-48.
    View publication on PubMed
Search for more literature for 6.3.2.17

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bacteria enzyme in biosynthesis of folylpolyglutamates , the most universal functions of folylpolyglutamates: 1. Actual cofactors in vivo for folate dependent enzymes, 2. Inhibitor of folate dependent enzymes for which they are not substrates, 3. Increases retention of folates after they are transported into cells as monoglutamates ?
-
 ?
additional information eukaryota enzyme in biosynthesis of folylpolyglutamates , the most universal functions of folylpolyglutamates: 1. Actual cofactors in vivo for folate dependent enzymes, 2. Inhibitor of folate dependent enzymes for which they are not substrates, 3. Increases retention of folates after they are transported into cells as monoglutamates ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bacteria
-
-
-
Corynebacterium sp.
-
-
-
eukaryota
-
-
-
Neurospora crassa
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate = ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1 the products are released in the order: ADP, 5,6,7,8-tetrahydropteroyl-Glu2, phosphate Corynebacterium sp.
a
ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate = ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1 sequential mechanism Corynebacterium sp.
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme in biosynthesis of folylpolyglutamates , the most universal functions of folylpolyglutamates: 1. Actual cofactors in vivo for folate dependent enzymes, 2. Inhibitor of folate dependent enzymes for which they are not substrates, 3. Increases retention of folates after they are transported into cells as monoglutamates Bacteria ?
-
 ?
additional information enzyme in biosynthesis of folylpolyglutamates , the most universal functions of folylpolyglutamates: 1. Actual cofactors in vivo for folate dependent enzymes, 2. Inhibitor of folate dependent enzymes for which they are not substrates, 3. Increases retention of folates after they are transported into cells as monoglutamates eukaryota ?
-
 ?