Inhibitors | Comment | Organism | Structure |
---|---|---|---|
7,8-dihydrofolate | noncompetitive with respect to dihydropteroate, competitive with respect to L-Glu | Neisseria gonorrhoeae | |
p-hydroxymercuribenzoate | - |
Neisseria gonorrhoeae | |
PCMB | - |
Neisseria gonorrhoeae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.035 | - |
7,8-dihydropteroate | - |
Neisseria gonorrhoeae | |
0.65 | - |
L-Glu | - |
Neisseria gonorrhoeae |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | maximal activity at 80 mM | Neisseria gonorrhoeae | |
K+ | monovalent cation requirement is satisfied by K+ or NH4+ | Neisseria gonorrhoeae | |
Mg2+ | divalent cation required, Mg2+ or Mn2+ | Neisseria gonorrhoeae | |
Mn2+ | divalent cation required | Neisseria gonorrhoeae | |
NH4+ | monovalent cation required, K+ or NH4+, maximal activity at 20 mM | Neisseria gonorrhoeae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Neisseria gonorrhoeae | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Neisseria gonorrhoeae |
Storage Stability | Organism |
---|---|
-60°C, stable | Neisseria gonorrhoeae |
4°C, 50% loss of activity after 6 weeks | Neisseria gonorrhoeae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 7,8-dihydropteroate + L-Glu | - |
Neisseria gonorrhoeae | ADP + phosphate + 7,8-dihydrofolate | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9.3 | - |
- |
Neisseria gonorrhoeae |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
8 | 9.5 | 8: about 25% of maximal activity, 9.5: about 85% of maximal activity | Neisseria gonorrhoeae |