Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Leishmania major |
Protein Variants | Comment | Organism |
---|---|---|
DELTAN236 | unable to produce trypanothione | Leishmania major |
DELTAN250 | unable to produce trypanothione | Leishmania major |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania major | Q711P7 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione + spermidine + ATP | - |
Leishmania major | glutathionylspermidine + ADP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Trypanothione synthetase | - |
Leishmania major |
TryS | the enzyme has two domains: an ATP-dependent synthetase domain that generates the intermediate glutathionylspermidine and the final product trypanothione from glutathione and spermidine, and an amidase domain which can hydrolyse glutathionylspermidine and trypanothione to the original substrates | Leishmania major |