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Literature summary for 6.3.1.8 extracted from

  • Chen, S.; Lin, C.H.; Kwon, D.S.; Walsh, C.T.; Coward, J.K.
    Design, synthesis, and biochemical evaluation of phosphonate and phosphonamidate analogs of glutathionylspermidine as inhibitors of glutathionylspermidine synthetase/amidase from Escherichia coli (1997), J. Med. Chem., 40, 3842-3850.
    View publication on PubMed
Search for more literature for 6.3.1.8

Inhibitors

Inhibitors Comment Organism Structure
Hydrogen O-[3-[N-(4-Aminobutyl)amino]propyl][[(gamma-glutamylalanyl)amino]methyl]phosphonate
-
 Escherichia coli
additional information design, synthesis, and biochemical evaluation of phosphonate and phosphonamidate analogs of glutathionylspermidine as inhibitors Escherichia coli
Non-polyamine-containing phosphoamidate
-
 Escherichia coli
Polyamine-containing phosphapeptides potent and selective Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
gamma-L-Glutamyl-L-cysteinyl-glycine + spermidine + ATP Escherichia coli key enzyme that participates in the first of two similar steps of trypanothione biosynthesis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
gamma-L-Glu-L-Cys-Gly + spermidine + ATP
-
 Escherichia coli N1-(gamma-L-Glu-L-Cys-Gly)-spermidine + ADP + phosphate
-
 ?
gamma-L-Glutamyl-L-cysteinyl-glycine + spermidine + ATP key enzyme that participates in the first of two similar steps of trypanothione biosynthesis Escherichia coli ?
-
 ?