Application | Comment | Organism |
---|---|---|
medicine | the first intron of the gene ASNS contains two 14-bp tandem repeat sequences, i.e. 2R. Approximately 75% of acute lymphoblastic leukemia samples have the 2R sequence in both alleles, 20% and 3% acute lymphoblastic leukemia samples have three and four 14-bp tandem repeats in one allele, respectively. The other allele has 2R. The tandem repeat sequence is not specific to the leukemia cells but represents a novel germline polymorphism. The 14-bp sequence functions as a transcriptional enhancer element as shown by reporter analysis and forms a protein-DNA complex in vitro | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
patients with acute lymphoblastic leukemia | - |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the first intron of the gene ASNS contains two 14-bp tandem repeat sequences, i.e. 2R. The 14-bp sequence functions as a transcriptional enhancer element as shown by reporter analysis and forms a protein-DNA complex in vitro | additional information |