Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-glutamate + NH3 | Rattus norvegicus | upon tissue damage, the enzyme endogenous GS is released from glial cells in the extracellular space, where it converts glutamate into glutamine, which is a nonneurotoxic amino acid | ADP + phosphate + L-glutamine | - |
? | |
additional information | Rattus norvegicus | glutamine synthetase protects the spinal cord against hypoxia-induced and GABA(A) receptor-activated axonal depressions, it may inhibit the depression of CAP amplitudes by blocking GABAA receptors, overview. GS significantly reduces the axonal depression effects of isoguvacine | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | - |
Rattus norvegicus | - |
glial cell | - |
Rattus norvegicus | - |
oligodendrocyte | - |
Rattus norvegicus | - |
spinal cord | and hemicord | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-glutamate + NH3 | - |
Rattus norvegicus | ADP + phosphate + L-glutamine | - |
? | |
ATP + L-glutamate + NH3 | upon tissue damage, the enzyme endogenous GS is released from glial cells in the extracellular space, where it converts glutamate into glutamine, which is a nonneurotoxic amino acid | Rattus norvegicus | ADP + phosphate + L-glutamine | - |
? | |
additional information | glutamine synthetase protects the spinal cord against hypoxia-induced and GABA(A) receptor-activated axonal depressions, it may inhibit the depression of CAP amplitudes by blocking GABAA receptors, overview. GS significantly reduces the axonal depression effects of isoguvacine | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Glutamine synthetase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
asay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |