Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.3.1.2 extracted from

  • Wray, L.V.; Fisher, S.H.
    Bacillus subtilis GlnR contains an autoinhibitory C-terminal domain required for the interaction with glutamine synthetase (2008), Mol. Microbiol., 68, 277-285.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
L-glutamine the enzyme is feedback inhibited Bacillus subtilis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-glutamate + NH3 Bacillus subtilis the enzyme is involved in the signal transduction for regulation of the nitrogen metabolism, overview ADP + phosphate + L-glutamine
-
?
additional information Bacillus subtilis the glutamine synthetase transmits the nitrogen regulatory signal to GlnR, a transcription factor involved in nitrogen metabolism regulation, the enzyme interacts with GlnR via the factor's C-terminal autoinhibitory domain, the protein-protein interaction of GlnR and glutamine synthetase stabilizes the GlnR-DNA complexes, interaction analysis of enzyme with wild-type and truncated GlnR proteins, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
gene glnA
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-glutamate + NH3
-
Bacillus subtilis ADP + phosphate + L-glutamine
-
?
ATP + L-glutamate + NH3 the enzyme is involved in the signal transduction for regulation of the nitrogen metabolism, overview Bacillus subtilis ADP + phosphate + L-glutamine
-
?
additional information the glutamine synthetase transmits the nitrogen regulatory signal to GlnR, a transcription factor involved in nitrogen metabolism regulation, the enzyme interacts with GlnR via the factor's C-terminal autoinhibitory domain, the protein-protein interaction of GlnR and glutamine synthetase stabilizes the GlnR-DNA complexes, interaction analysis of enzyme with wild-type and truncated GlnR proteins, overview Bacillus subtilis ?
-
?

Synonyms

Synonyms Comment Organism
GlnR
-
Bacillus subtilis
Glutamine synthetase
-
Bacillus subtilis

Cofactor

Cofactor Comment Organism Structure
ATP
-
Bacillus subtilis