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Literature summary for 6.3.1.15 extracted from
- CouO and NovO: C-methyltransferases for tailoring the aminocoumarin scaffold in coumermycin and novobiocin antibiotic biosynthesis (2005), Biochemistry, 44, 14969-14976.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 3-dimethylallyl-4-hydroxybenzoate + 3-amino-4,7-dihydroxycoumarin | Streptomyces niveus | the enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin | AMP + diphosphate + 8-demethylnovobiocic acid | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces niveus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 3-dimethylallyl-4-hydroxybenzoate + 3-amino-4,7-dihydroxycoumarin | - |
Streptomyces niveus | AMP + diphosphate + 8-demethylnovobiocic acid | - |
? | |
| ATP + 3-dimethylallyl-4-hydroxybenzoate + 3-amino-4,7-dihydroxycoumarin | the enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin | Streptomyces niveus | AMP + diphosphate + 8-demethylnovobiocic acid | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NovL | - |
Streptomyces niveus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the enzyme is involved in the biosynthesis of the aminocoumarin antibiotic novobiocin | Streptomyces niveus |
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