Literature summary for 6.3.1.13 extracted from

Dosanjh, M.; Newton, G.L.; Davies, J.
Characterization of a mycothiol ligase mutant of Rhodococcus jostii RHA1 (2008), Res. Microbiol., 159, 643-650.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + L-cysteine + ATP	Rhodococcus jostii	inactivation of the mshC gene in RHA1 results in the accumulation of the MSH pathway intermediate, 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside. The mutant is deficient in the biochemical degradation of a number of xenobiotics metabolized by the parent strain, it shows increased susceptibility to a number of antibiotics and it shows unusual growth characteristics, exhibiting a long lag phase before normal exponential growth	1-O-[2-(L-cysteinamido)-2-deoxy-alpha-D-glucopyranosyl]-1D-myo-inositol + AMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Rhodococcus jostii	-	RHA1, generation of an MshC mutant (RHA1_022) in RHA1	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + L-cysteine + ATP	inactivation of the mshC gene in RHA1 results in the accumulation of the MSH pathway intermediate, 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside. The mutant is deficient in the biochemical degradation of a number of xenobiotics metabolized by the parent strain, it shows increased susceptibility to a number of antibiotics and it shows unusual growth characteristics, exhibiting a long lag phase before normal exponential growth	Rhodococcus jostii	1-O-[2-(L-cysteinamido)-2-deoxy-alpha-D-glucopyranosyl]-1D-myo-inositol + AMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
MshC	-	Rhodococcus jostii

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Release 2023.1 (January 2023)