Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.2.1.7 extracted from

  • Kwakye, J.B.; Barnes, S.; Diasio, R.B.
    Identification of bile acid coenzyme A synthetase in rat kidney (1993), J. Lipid Res., 34, 95-99.
    View publication on PubMed
Search for more literature for 6.2.1.7

Inhibitors

Inhibitors Comment Organism Structure
EDTA
-
 Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ stimulates up to a maximal concentration of 5 mM Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + cholate + CoA Rattus norvegicus kidney has the potential for bile acid metabolism and may have a role in bile acid physiology. Conjugation of bile acids in the kidney may serve as a protective mechanism by which the renal cell avoids injury from circulating unconjugated bile acids AMP + diphosphate + choloyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + chenodeoxycholate + CoA
-
 Rattus norvegicus AMP + diphosphate + chenodeoxycholoyl-CoA
-
 ?
ATP + cholate + CoA kidney has the potential for bile acid metabolism and may have a role in bile acid physiology. Conjugation of bile acids in the kidney may serve as a protective mechanism by which the renal cell avoids injury from circulating unconjugated bile acids Rattus norvegicus AMP + diphosphate + choloyl-CoA
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
 Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6.5 9.8 6.5: about 30% of maximal activity, 9.8: about 50% of maximal activity Rattus norvegicus