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Literature summary for 6.2.1.65 extracted from

  • Ishiyama, D.; Vujaklija, D.; Davies, J.
    Novel pathway of salicylate degradation by Streptomyces sp. strain WA46 (2004), Appl. Environ. Microbiol., 70, 1297-1306 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.2.1.65

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Streptomyces sp. WA46

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2-hydroxybenzoyl)adenylate + CoA Streptomyces sp. WA46
-
 AMP + 2-hydroxybenzoyl-CoA
-
 ?
ATP + salicylate Streptomyces sp. WA46
-
 diphosphate + (2-hydroxybenzoyl)adenylate
-
 ?
ATP + salicylate + CoA Streptomyces sp. WA46
-
 AMP + diphosphate + 2-hydroxybenzoyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces sp. WA46 Q7X279
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2-hydroxybenzoyl)adenylate + CoA
-
 Streptomyces sp. WA46 AMP + 2-hydroxybenzoyl-CoA
-
 ?
ATP + salicylate
-
 Streptomyces sp. WA46 diphosphate + (2-hydroxybenzoyl)adenylate
-
 ?
ATP + salicylate + CoA
-
 Streptomyces sp. WA46 AMP + diphosphate + 2-hydroxybenzoyl-CoA
-
 ?
additional information no substrates: benzoate, 3-hydroxybenzoate, 4-hydroxybenzoate, gentisate, 2-aminobenzoate, salicylamide, salicylaldoxime, and 2-hydroxyphenyl acetate Streptomyces sp. WA46 ?
-
-

Synonyms

Synonyms Comment Organism
salicylyl-CoA synthase/salicylate adenylyltransferase
-
 Streptomyces sp. WA46
sdgA
-
 Streptomyces sp. WA46

Cofactor

Cofactor Comment Organism Structure
CoA
-
 Streptomyces sp. WA46

General Information

General Information Comment Organism
physiological function disruption of the SdgA gene blocks salicylate degradation. Cell extracts from Escherichia coli transformants expressing each of the SdgABCDEFGHR genes show that SdgA, SdgC, ATP, CoA, and NADH are necessary to convert salicylate to gentisate. SdgA requires CoA and ATP as cofactors Streptomyces sp. WA46