Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.2.1.51 extracted from

  • Simeone, R.; Leger, M.; Constant, P.; Malaga, W.; Marrakchi, H.; Daffe, M.; Guilhot, C.; Chalut, C.
    Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis (2010), FEBS J., 277, 2715-2725.
    View publication on PubMed
Search for more literature for 6.2.1.51

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 17-(4-hydroxyphenyl)heptadecanoate Mycobacterium tuberculosis
-
 diphosphate + 17-(4-hydroxyphenyl)heptadecanoyl adenylate
-
 ?
ATP + 17-(4-hydroxyphenyl)heptadecanoate Mycobacterium tuberculosis H37Rv
-
 diphosphate + 17-(4-hydroxyphenyl)heptadecanoyl adenylate
-
 ?
ATP + 19-(4-hydroxyphenyl)nonadecanoate Mycobacterium tuberculosis
-
 diphosphate + 19-(4-hydroxyphenyl)nonadecanoyl adenylate
-
 ?
ATP + 19-(4-hydroxyphenyl)nonadecanoate Mycobacterium tuberculosis H37Rv
-
 diphosphate + 19-(4-hydroxyphenyl)nonadecanoyl adenylate
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P95141
-
-
Mycobacterium tuberculosis H37Rv P95141
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 17-(4-hydroxyphenyl)heptadecanoate
-
 Mycobacterium tuberculosis diphosphate + 17-(4-hydroxyphenyl)heptadecanoyl adenylate
-
 ?
ATP + 17-(4-hydroxyphenyl)heptadecanoate
-
 Mycobacterium tuberculosis H37Rv diphosphate + 17-(4-hydroxyphenyl)heptadecanoyl adenylate
-
 ?
ATP + 19-(4-hydroxyphenyl)nonadecanoate
-
 Mycobacterium tuberculosis diphosphate + 19-(4-hydroxyphenyl)nonadecanoyl adenylate
-
 ?
ATP + 19-(4-hydroxyphenyl)nonadecanoate
-
 Mycobacterium tuberculosis H37Rv diphosphate + 19-(4-hydroxyphenyl)nonadecanoyl adenylate
-
 ?
ATP + laurate
-
 Mycobacterium tuberculosis diphosphate + lauroyl adenylate
-
 ?
ATP + laurate
-
 Mycobacterium tuberculosis H37Rv diphosphate + lauroyl adenylate
-
 ?

Synonyms

Synonyms Comment Organism
fadD29
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
physiological function FadD29 protein is not required for the production of phthiocerol and phthiodiolone dimycocerosates in Mycobacterium tuberculosis. The protein is involved in the biosynthesis of phenolic glycolipids. During the formation of the phenolphthiocerol chain, FadD22 catalyzes the activation of 4-hydroxybenoic acid and its subsequent transfer onto polyketide synthase PKS15, to yield 4-hydroxyphenylalkanoate. This latter lipid is then activated by FadD29 Mycobacterium tuberculosis