BRENDA - Enzyme Database show
show all sequences of 6.2.1.5

Citric acid cycle enzymes of the archaebacteria: citrate synthase and succinate thiokinase

Danson, M.J.; Black, S.C.; Woodland, D.L.; Wood, P.A.; FEBS Lett. 179, 120-124 (1985)
No PubMed abstract available

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
2-oxoglutarate
-
Bacillus megaterium
2-oxoglutarate
-
Escherichia coli
2-oxoglutarate
no inhibition
Halobacterium salinarum
2-oxoglutarate
-
Haloferax volcanii
2-oxoglutarate
-
Natronobacterium gregoryi
2-oxoglutarate
no inhibition
Natronomonas pharaonis
2-oxoglutarate
-
Sulfolobus acidocaldarius
2-oxoglutarate
no inhibition
Sus scrofa
2-oxoglutarate
-
Thermoplasma acidophilum
ATP
-
Bacillus megaterium
ATP
-
Escherichia coli
ATP
-
Halobacterium salinarum
ATP
-
Haloferax volcanii
ATP
-
Natronobacterium gregoryi
ATP
-
Natronomonas pharaonis
ATP
-
Sulfolobus acidocaldarius
ATP
-
Sus scrofa
ATP
-
Thermoplasma acidophilum
NADH
-
Bacillus megaterium
NADH
-
Escherichia coli
NADH
-
Halobacterium salinarum
NADH
-
Haloferax volcanii
NADH
-
Natronobacterium gregoryi
NADH
-
Natronomonas pharaonis
NADH
-
Sulfolobus acidocaldarius
NADH
-
Sus scrofa
NADH
-
Thermoplasma acidophilum
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
68000
-
gel filtration
Thermoplasma acidophilum
75000
-
gel filtration
Bacillus megaterium
75000
-
gel filtration
Sus scrofa
136000
-
gel filtration
Escherichia coli
170000
-
gel filtration
Haloferax volcanii
171000
-
gel filtration
Natronobacterium gregoryi
174000
-
gel filtration
Haloarcula vallismortis
174000
-
gel filtration
Natronomonas pharaonis
184000
-
gel filtration
Natronococcus occultus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bacillus megaterium
-
-
-
Escherichia coli
-
-
-
Haloarcula vallismortis
-
-
-
Halobacterium salinarum
-
-
-
Haloferax volcanii
-
-
-
Natronobacterium gregoryi
-
-
-
Natronococcus occultus
-
-
-
Natronomonas pharaonis
-
-
-
Sulfolobus acidocaldarius
-
strain DSM639
-
Sulfolobus acidocaldarius DSM 639
-
strain DSM639
-
Sus scrofa
-
-
-
Thermoplasma acidophilum
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
heart
-
Sus scrofa
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + succinate + CoA
no activity with GTP/GDP
799
Escherichia coli
ADP + phosphate + succinyl-CoA
-
-
-
-
ATP + succinate + CoA
no activity with GTP/GDP
799
Sus scrofa
ADP + phosphate + succinyl-CoA
-
-
-
-
ATP + succinate + CoA
no activity with GTP/GDP
799
Bacillus megaterium
ADP + phosphate + succinyl-CoA
-
-
-
-
ATP + succinate + CoA
no activity with GTP/GDP
799
Halobacterium salinarum
ADP + phosphate + succinyl-CoA
-
-
-
-
ATP + succinate + CoA
no activity with GTP/GDP
799
Haloarcula vallismortis
ADP + phosphate + succinyl-CoA
-
-
-
-
ATP + succinate + CoA
no activity with GTP/GDP
799
Haloferax volcanii
ADP + phosphate + succinyl-CoA
-
-
-
-
ATP + succinate + CoA
no activity with GTP/GDP
799
Natronomonas pharaonis
ADP + phosphate + succinyl-CoA
-
-
-
-
ATP + succinate + CoA
no activity with GTP/GDP
799
Natronobacterium gregoryi
ADP + phosphate + succinyl-CoA
-
-
-
-
ATP + succinate + CoA
no activity with GTP/GDP
799
Natronococcus occultus
ADP + phosphate + succinyl-CoA
-
-
-
-
ATP + succinate + CoA
no activity with GTP/GDP
799
Sulfolobus acidocaldarius
ADP + phosphate + succinyl-CoA
-
-
-
-
ATP + succinate + CoA
no activity with GTP/GDP
799
Thermoplasma acidophilum
ADP + phosphate + succinyl-CoA
-
-
-
-
ATP + succinate + CoA
no activity with GTP/GDP
799
Sulfolobus acidocaldarius DSM 639
ADP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Escherichia coli
GDP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Sus scrofa
GDP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Bacillus megaterium
GDP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Halobacterium salinarum
GDP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Haloarcula vallismortis
GDP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Haloferax volcanii
GDP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Natronomonas pharaonis
GDP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Natronobacterium gregoryi
GDP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Natronococcus occultus
GDP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Sulfolobus acidocaldarius
GDP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Thermoplasma acidophilum
GDP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Sulfolobus acidocaldarius DSM 639
GDP + phosphate + succinyl-CoA
-
-
-
-
Subunits
Subunits
Commentary
Organism
dimer
-
Bacillus megaterium
dimer
-
Sus scrofa
tetramer
-
Escherichia coli
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2-oxoglutarate
-
Bacillus megaterium
2-oxoglutarate
-
Escherichia coli
2-oxoglutarate
no inhibition
Halobacterium salinarum
2-oxoglutarate
-
Haloferax volcanii
2-oxoglutarate
-
Natronobacterium gregoryi
2-oxoglutarate
no inhibition
Natronomonas pharaonis
2-oxoglutarate
-
Sulfolobus acidocaldarius
2-oxoglutarate
no inhibition
Sus scrofa
2-oxoglutarate
-
Thermoplasma acidophilum
ATP
-
Bacillus megaterium
ATP
-
Escherichia coli
ATP
-
Halobacterium salinarum
ATP
-
Haloferax volcanii
ATP
-
Natronobacterium gregoryi
ATP
-
Natronomonas pharaonis
ATP
-
Sulfolobus acidocaldarius
ATP
-
Sus scrofa
ATP
-
Thermoplasma acidophilum
NADH
-
Bacillus megaterium
NADH
-
Escherichia coli
NADH
-
Halobacterium salinarum
NADH
-
Haloferax volcanii
NADH
-
Natronobacterium gregoryi
NADH
-
Natronomonas pharaonis
NADH
-
Sulfolobus acidocaldarius
NADH
-
Sus scrofa
NADH
-
Thermoplasma acidophilum
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
68000
-
gel filtration
Thermoplasma acidophilum
75000
-
gel filtration
Bacillus megaterium
75000
-
gel filtration
Sus scrofa
136000
-
gel filtration
Escherichia coli
170000
-
gel filtration
Haloferax volcanii
171000
-
gel filtration
Natronobacterium gregoryi
174000
-
gel filtration
Haloarcula vallismortis
174000
-
gel filtration
Natronomonas pharaonis
184000
-
gel filtration
Natronococcus occultus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
heart
-
Sus scrofa
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ATP + succinate + CoA
no activity with GTP/GDP
799
Escherichia coli
ADP + phosphate + succinyl-CoA
-
-
-
-
ATP + succinate + CoA
no activity with GTP/GDP
799
Sus scrofa
ADP + phosphate + succinyl-CoA
-
-
-
-
ATP + succinate + CoA
no activity with GTP/GDP
799
Bacillus megaterium
ADP + phosphate + succinyl-CoA
-
-
-
-
ATP + succinate + CoA
no activity with GTP/GDP
799
Halobacterium salinarum
ADP + phosphate + succinyl-CoA
-
-
-
-
ATP + succinate + CoA
no activity with GTP/GDP
799
Haloarcula vallismortis
ADP + phosphate + succinyl-CoA
-
-
-
-
ATP + succinate + CoA
no activity with GTP/GDP
799
Haloferax volcanii
ADP + phosphate + succinyl-CoA
-
-
-
-
ATP + succinate + CoA
no activity with GTP/GDP
799
Natronomonas pharaonis
ADP + phosphate + succinyl-CoA
-
-
-
-
ATP + succinate + CoA
no activity with GTP/GDP
799
Natronobacterium gregoryi
ADP + phosphate + succinyl-CoA
-
-
-
-
ATP + succinate + CoA
no activity with GTP/GDP
799
Natronococcus occultus
ADP + phosphate + succinyl-CoA
-
-
-
-
ATP + succinate + CoA
no activity with GTP/GDP
799
Sulfolobus acidocaldarius
ADP + phosphate + succinyl-CoA
-
-
-
-
ATP + succinate + CoA
no activity with GTP/GDP
799
Thermoplasma acidophilum
ADP + phosphate + succinyl-CoA
-
-
-
-
ATP + succinate + CoA
no activity with GTP/GDP
799
Sulfolobus acidocaldarius DSM 639
ADP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Escherichia coli
GDP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Sus scrofa
GDP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Bacillus megaterium
GDP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Halobacterium salinarum
GDP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Haloarcula vallismortis
GDP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Haloferax volcanii
GDP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Natronomonas pharaonis
GDP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Natronobacterium gregoryi
GDP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Natronococcus occultus
GDP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Sulfolobus acidocaldarius
GDP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Thermoplasma acidophilum
GDP + phosphate + succinyl-CoA
-
-
-
-
GTP + succinate + CoA
no activity with GDP/GTP
799
Sulfolobus acidocaldarius DSM 639
GDP + phosphate + succinyl-CoA
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
-
Bacillus megaterium
dimer
-
Sus scrofa
tetramer
-
Escherichia coli
Other publictions for EC 6.2.1.5
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
745783
Huang
Succinyl-CoA synthetase (SUCL ...
Homo sapiens
Mol. Genet. Metab.
120
213-222
2017
-
-
-
-
2
-
-
1
-
-
-
2
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
2
-
-
-
-
1
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
746481
Zhao
Loss of succinyl-CoA synthase ...
Mus musculus
Sci. Rep.
7
7169
2017
-
-
-
-
-
-
-
-
1
-
-
2
-
1
-
-
-
-
-
1
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
750677
Zhong
Differential gene expression ...
Pleurotus ostreatus
Fungal Biol.
121
1025-1036
2017
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
744272
Kacso
Two transgenic mouse models f ...
Mus musculus
Biochem. J.
473
3463-3485
2016
-
-
-
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
3
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
745500
Carrozzo
Succinate-CoA ligase deficien ...
Homo sapiens
J. Inherit. Metab. Dis.
39
243-252
2016
-
-
-
-
6
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
6
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
746174
Gomes
Succinyl-CoA synthetase New a ...
Bartonella bacilliformis
PLoS Negl. Trop. Dis.
10
e0004989
2016
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
726747
Nolte
Novel characteristics of succi ...
Advenella mimigardefordensis, Advenella mimigardefordensis DPN7, Alcanivorax borkumensis, Alcanivorax borkumensis SK2, Escherichia coli K-12, Escherichia coli K-12 BL21
Appl. Environ. Microbiol.
80
166-176
2014
-
-
3
-
-
-
-
20
-
-
-
24
-
17
-
-
3
-
-
-
3
-
66
-
3
-
-
20
3
-
-
8
-
-
-
-
-
6
16
-
-
-
-
-
-
40
-
-
-
24
-
-
-
6
-
-
6
-
66
-
6
-
-
40
6
-
-
-
-
1
2
-
20
40
745498
Luis
Valproyl-CoA inhibits the act ...
Homo sapiens
J. Inherit. Metab. Dis.
37
353-357
2014
-
-
-
-
-
-
3
1
1
-
-
2
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
3
-
1
1
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
728078
Luis
Valproyl-CoA inhibits the acti ...
Homo sapiens
J. Inherit. Metab. Dis.
37
353-357
2013
-
-
-
-
-
-
3
-
1
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
3
-
-
1
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
3
3
-
-
-
727919
Bishop
X-linked sideroblastic anemia ...
Homo sapiens
J. Biol. Chem.
287
28943-28955
2012
-
1
1
-
-
-
-
-
1
-
-
1
-
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
714342
Miller
The interplay between SUCLA2, ...
Homo sapiens
Biochim. Biophys. Acta
1812
625-629
2011
-
-
1
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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1
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Functional consequences of sub ...
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Site-directed mutagenesis of E ...
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1
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Native-like intermediate on th ...
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1
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Cloning and expression of the ...
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1753-1762
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2
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3
1
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797
Allen
Succinate thiokinase in pigeon ...
Pigeon
FEBS Lett.
194
171-175
1986
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1
1
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3
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1
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1
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1
1
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798
Buck
Primary structure of the succi ...
Escherichia coli
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24
6245-6252
1985
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1
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2
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1
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1
1
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799
Danson
-
Citric acid cycle enzymes of t ...
Bacillus megaterium, Escherichia coli, Haloarcula vallismortis, Halobacterium salinarum, Haloferax volcanii, Natronobacterium gregoryi, Natronococcus occultus, Natronomonas pharaonis, Sulfolobus acidocaldarius, Sulfolobus acidocaldarius DSM 639, Sus scrofa, Thermoplasma acidophilum
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1985
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27
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27
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1
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24
3
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27
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9
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1
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24
3
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800
Wolodko
Crystallization of succinyl-Co ...
Escherichia coli
J. Biol. Chem.
259
5316-5320
1984
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1
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801
Weitzman
-
Succinate thiokinase from Ther ...
Escherichia coli, Halobacterium salinarum, Thermus aquaticus
FEBS Lett.
154
369-372
1983
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2
2
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3
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2
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10
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2
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2
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10
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788
Weitzman
Pattern of nucleotide utilizat ...
Alcaligenes faecalis, Bacillus megaterium, Brevibacterium linens, Escherichia coli, Geobacillus stearothermophilus, Klebsiella aerogenes, Kurthia zopfii, More, Paracoccus denitrificans, Pimelobacter simplex, Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas stutzeri, Rhodobacter sphaeroides, Salmonella enterica subsp. arizonae, Serratia marcescens, Thermus aquaticus
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1982
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29
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29
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803
Hamilton
An ATP-dependent succinic thio ...
Gallus gallus, Pigeon
FEBS Lett.
123
252-254
1981
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2
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9
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9
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2
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814
Wider de Xifra
Porphyrin biosynthesis: immobi ...
Glycine max
Biochim. Biophys. Acta
523
245-249
1978
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1
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4
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1
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1
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1
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2
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2
2
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1
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4
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1
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1
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1
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2
2
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2
2
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815
Nishimura
Inactivation of Escherichia co ...
Escherichia coli
Biochem. Biophys. Res. Commun.
69
1057-1064
1976
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1
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804
Pearson
Isolation of the alpha and bet ...
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4451-4455
1975
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1
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1
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1
1
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806
Thomas
Studies on the metabolism of A ...
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163
530-536
1974
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2
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807
Krebs
Some physical parameters of su ...
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52
594-598
1974
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3
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1
2
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808
Hansford
An adenine nucleotide-linked s ...
Calliphoridae
FEBS Lett.
31
317-320
1973
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4
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1
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1
1
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1
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4
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1
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1
1
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1
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-
-
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809
Moffet
Succinyl coenzyme A synthetase ...
Escherichia coli
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8139-8144
1972
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2
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1
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1
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2
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-
1
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810
Murakami
Nucleotide specificity of Esch ...
Escherichia coli
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247
6247-6252
1972
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1
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4
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4
-
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805
Wider
Porphyrin biosynthesis in soyb ...
Glycine max
Enzymologia
41
217-231
1971
3
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25
2
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2
1
1
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1
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1
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1
1
1
3
-
1
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1
1
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3
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25
-
2
-
2
1
1
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1
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1
1
1
3
-
1
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1
1
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811
Hager
-
Succinyl CoA synthetase ...
Escherichia coli, Spinacia oleracea, Sus scrofa
The Enzymes, 2nd Ed (Boyer, P. D. , Lardy, H. , Myrbäck, K. , eds. )
6
387-399
1962
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3
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1
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3
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1
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5
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3
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5
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